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A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity.

作者信息

Ghosh Arun K, Liu Wenming, Xu Yibo, Chen Zhidong

机构信息

Department of Chemistry, University of Illinois at Chicago 845 West Taylor Street, Chicago, IL 60607 (USA).

出版信息

Angew Chem Int Ed Engl. 1996 Jan 19;35(1):74-76. doi: 10.1002/anie.199600741.

DOI:10.1002/anie.199600741
PMID:30344446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6195359/
Abstract
摘要

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STEREOSELECTIVE REDUCTION OF α-HYDROXY OXIME ETHERS: A CONVENIENT ROUTE TO CIS-1,2-AMINO ALCOHOLS.α-羟基肟醚的立体选择性还原：合成顺式-1,2-氨基醇的便捷途径。
Tetrahedron Lett. 1991 Feb 4;32(6):711-714. doi: 10.1016/S0040-4039(00)74864-7. Epub 2001 Mar 9.
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Highly Enantioselective Aldol Reaction: Development of a New Chiral Auxiliary from -1-Amino-2-hydroxyindan.高度对映选择性羟醛反应：基于-1-氨基-2-羟基茚开发新型手性助剂
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Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.
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Science. 1983 Sep 23;221(4617):1285-8. doi: 10.1126/science.6137059.
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Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.维拉帕米与阿霉素治疗耐药性卵巢癌患者
J Clin Oncol. 1987 Apr;5(4):641-7. doi: 10.1200/JCO.1987.5.4.641.
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The biochemistry of P-glycoprotein-mediated multidrug resistance.P-糖蛋白介导的多药耐药的生物化学
Annu Rev Biochem. 1989;58:137-71. doi: 10.1146/annurev.bi.58.070189.001033.
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Multidrug resistance.多重耐药性
Annu Rev Med. 1991;42:277-86. doi: 10.1146/annurev.me.42.020191.001425.
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Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.
J Med Chem. 1992 May 15;35(10):1685-701. doi: 10.1021/jm00088a003.