Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy.
Phytomedicine. 2010 Oct;17(12):987-91. doi: 10.1016/j.phymed.2010.02.010. Epub 2010 Mar 31.
At present Griffonia simplicifolia is used in food supplement aimed to treat mood disorders as well as to reduce food intake and body weight. The plant has gained increasing interest for its high content in 5-hydroxy-L-tryptophan (5-HTP) particularly in the seed. The present study was designed to evaluate the influence of a seed extract of the plant, dosed at 25, 50 and 100 mg/kg, on the sexual behavior of ovariectomized hormone-primed rats after acute and subchronic treatment. The single administration of G. simplicifolia significantly reduced lordosis response and increased rejection behavior in female rats treated with the highest dose while it did not influence proceptive behaviors. On the other hand the subchronic administration of the extract significantly reduced proceptivity but not receptivity, and increased rejection behavior. All the tested dosages were able to markedly decrease food intake and body weight after a 9-day treatment. Taken together the present results, possibly ascribed to increased levels of 5-hydroxytryptamine (5-HT) in the brain, suggest a cautious administration of the plant extract owing to its negative influence on female sexual behavior.
目前，非洲臀果木被用于食品补充剂，以治疗情绪障碍，以及减少食物摄入和体重。由于其富含 5-羟色氨酸（5-HTP），特别是在种子中，该植物引起了越来越多的关注。本研究旨在评估植物种子提取物（剂量为 25、50 和 100mg/kg）对去卵巢激素预处理大鼠急性和亚慢性处理后性行为的影响。单次给予非洲臀果木提取物可显著降低最高剂量处理的雌性大鼠的摆尾反应并增加拒绝行为，而不影响求爱行为。另一方面，提取物的亚慢性给药显著降低了求爱行为，但不影响接受行为，并且增加了拒绝行为。所有测试剂量在 9 天的治疗后均能显著减少食物摄入和体重。综合来看，这些结果可能归因于大脑中 5-羟色胺（5-HT）水平的升高，提示谨慎使用植物提取物，因为它对雌性性行为有负面影响。
