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健康相关生活质量:退行性脊柱滑脱症后路融合术与大关节置换术后结果的比较及与人群正常值的比较。

Health-related quality of life: a comparison of outcomes after lumbar fusion for degenerative spondylolisthesis with large joint replacement surgery and population norms.

机构信息

Department of Spinal Surgery, The Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales 2109, Australia.

出版信息

Spine J. 2010 Apr;10(4):306-12. doi: 10.1016/j.spinee.2010.01.018.

Abstract

BACKGROUND CONTEXT

Degenerative spine disease will become an increasing health problem, and a significant number of patients will be considered for surgery. Spinal surgeries have evolved since the last decades, and there is a positive impact on the clinical outcomes. Few works in the literature have reviewed the outcome compared with large joint replacement surgery, which is considered a benchmark for operative restoration of patients' quality of life.

PURPOSE

The purpose of this study was to investigate if spinal fusion can return patients' health-related quality of life to that of age-matched population norms and yield outcomes comparable with those of total hip and knee joint replacement.

STUDY DESIGN

This is a prospective cohort study.

PATIENT SAMPLE

The sample consists of 100 consecutive patients who were enrolled between December 1997 and January 2007.

OUTCOME MEASURES

The 12-item Short Form Health Survey (SF-12) was chosen for outcome measurement.

METHODS

All patients underwent wide decompressive laminectomy and single-level posterior lumbar interbody fusion for spinal stenosis associated with degenerative spondylolisthesis.

RESULTS

The preoperative and postoperative physical component summary (PCS)-12 scores of the spinal fusion patients were comparable with those of both the total knee and hip replacement patients. The mean improvement in PCS-12 scores after spine surgery was 11 (95% confidence interval [CI]: 9-14, p<.0001). It was equal to that after total hip replacement surgery, which was 11 (95% CI: 9-13), and higher than that of total knee replacement patients, which had an improvement of 8 (95% CI: 7-9). The postoperative mean and 95% CI of the PCS-12 scores for the three surgical procedures approached the population norm value of 44 (95% CI: 43-46).There was no statistical difference between the postoperative mental component summary-12 score among all the three surgical groups, which approached similar to the population norm value of 54 (95% CI: 53-54).

CONCLUSIONS

The current study demonstrated that spinal surgery can return patients' HRQL to that of age-matched population norms and yield outcomes comparable with those of total hip and knee joint replacement patients.

摘要

背景

退行性脊柱疾病将成为一个日益严重的健康问题,大量患者将需要考虑手术治疗。脊柱手术自过去几十年以来已经发展,对临床结果产生了积极的影响。尽管有一些文献综述了手术效果,但与全髋关节和膝关节置换术相比,后者被认为是患者生活质量恢复的基准手术,与之相比的相关研究却很少。

目的

本研究旨在探讨脊柱融合是否可以使患者的健康相关生活质量恢复到与年龄匹配的人群正常值一致,并获得与全髋关节和全膝关节置换术相当的结果。

研究设计

这是一项前瞻性队列研究。

患者样本

该样本包括 1997 年 12 月至 2007 年 1 月期间连续入组的 100 例患者。

研究结果

选择 12 项简明健康调查量表(SF-12)作为结局测量指标。所有患者均接受广泛的减压性椎板切除术和单节段后路腰椎体间融合术治疗退行性脊柱滑脱伴椎管狭窄症。

结果

脊柱融合患者的术前和术后物理成分综合评分(PCS-12)与全膝关节和全髋关节置换患者相当。脊柱手术后 PCS-12 评分的平均改善为 11 分(95%置信区间[CI]:9-14,p<.0001),与全髋关节置换手术相当(11 分[95%CI:9-13]),高于全膝关节置换患者(改善 8 分[95%CI:7-9])。三种手术方式的术后 PCS-12 评分的平均和 95%CI 值均接近人群正常值 44(95%CI:43-46)。三组患者术后的精神成分综合评分-12 分无统计学差异,接近人群正常值 54(95%CI:53-54)。

结论

本研究表明,脊柱手术可以使患者的 HRQL 恢复到与年龄匹配的人群正常值一致,并获得与全髋关节和全膝关节置换患者相当的结果。

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