用于小动物成像的切伦科夫发光断层扫描。
Cerenkov luminescence tomography for small-animal imaging.
机构信息
Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA.
出版信息
Opt Lett. 2010 Apr 1;35(7):1109-11. doi: 10.1364/OL.35.001109.
Abstract
Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from beta-emitting radiotracers such as (18)F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.
摘要
切伦科夫辐射是一种熟知的现象，其中光光子由比介质中光速更快运动的带电粒子发射。我们已经使用灵敏的 CCD 相机观察到了由β发射放射性示踪剂（如 18F-氟脱氧葡萄糖）发射的切伦科夫光子。幻影和体内小鼠成像实验已经证明，通过用扩散方程模拟光学光子的传播并使用预处理共轭梯度方法迭代地重建光学发射源分布，可以利用发射的切伦科夫光光子的表面测量来重建物体内部放射性示踪剂的活性分布。
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