Department of nutrition, Université de Montréal, Pavillon Liliane-de-Stewart, Montréal, Québec, Canada.
Int J Obes (Lond). 2010 Sep;34(9):1387-95. doi: 10.1038/ijo.2010.55. Epub 2010 Apr 6.
Chronic subclinical inflammation and regular physical activity have opposing relationships to obesity-related metabolic diseases. Yet, the association between chronic inflammation and physical activity has rarely been examined in obese subjects. We examined the association between physical activity energy expenditure (PAEE), total (TEE) and resting energy expenditure (REE) and cardiorespiratory fitness (VO(2)peak) with inflammatory markers in overweight/obese women.
Cross-sectional study.
The study included 152 overweight/obese postmenopausal women who were sedentary and free of chronic/inflammatory diseases (mean age: 57.5 (95% confidence interval (CI) 56.7-58.3) years, body mass index (BMI): 32.5 (95% CI 31.8-33.2) kg m(-2)). The following parameters were measured: TEE (doubly labeled water), REE (indirect calorimetry), PAEE (as (TEE x 0.90)-REE), VO(2)peak (ergocycle) and serum high-sensitive C-reactive protein (hsCRP), haptoglobin, soluble tumor necrosis factor-α receptor 1 (sTNFR1), interleukin-6, orosomucoid and white blood cells.
Sedentary women with the highest tertile of PAEE (1276 (1233-1319) kcal day(-1)) had lower concentrations of hsCRP and haptoglobin than those in the lowest tertile (587 (553-621) kcal day(-1)) after adjustment for fat mass (P<0.05). Soluble TNFR1 was positively correlated with VO(2)peak, TEE and REE (P<0.05), and hsCRP and orosomucoid were positively associated with REE (P<0.01), whereas haptoglobin was negatively associated with PAEE (P<0.05). In stepwise regression analyses that examined the concomitant associations of components of energy expenditure with inflammatory markers, PAEE remained the only predictor of hsCRP and haptoglobin (P<0.05), explaining 14 and 5%, respectively, of their variation,whereas REE was the only predictor of orosomucoid (r (2) = 0.05, P = 0.02) after adjustment for fat mass. Adding leptin to the regression models results in similar relationships between inflammatory markers and components of energy expenditure.
PAEE is an independent predictor of hsCRP and haptoglobin in sedentary overweight/obese postmenopausal women free of chronic disease. Our data support the role of physical activity in reducing subclinical inflammation and risk of metabolic and cardiovascular diseases.
慢性亚临床炎症和规律的身体活动与肥胖相关代谢性疾病呈负相关。然而，肥胖人群中慢性炎症与身体活动之间的关系很少被研究。我们检测了超重/肥胖绝经后女性的身体活动能量消耗（PAEE）、总能量消耗（TEE）和静息能量消耗（REE）以及心肺功能（VO （2）峰值）与炎症标志物之间的相关性。
横断面研究。
该研究纳入了 152 名久坐且无慢性/炎症性疾病的超重/肥胖绝经后妇女（平均年龄：57.5（95%置信区间（CI）56.7-58.3）岁，体重指数（BMI）：32.5（95% CI 31.8-33.2）kg/m （2））。测量了以下参数：TEE（双标记水）、REE（间接测热法）、PAEE（（TEE x 0.90）-REE）、VO （2）峰值（ergocycle）和血清高敏 C 反应蛋白（hsCRP）、触珠蛋白、可溶性肿瘤坏死因子-α受体 1（sTNFR1）、白细胞介素-6、血清黏蛋白。
在调整脂肪量后，PAEE 最高 tertile（1276（1233-1319）kcal/day）的久坐女性 hsCRP 和触珠蛋白浓度低于最低 tertile（587（553-621）kcal/day）（P<0.05）。可溶性 TNFR1 与 VO （2）峰值、TEE 和 REE 呈正相关（P<0.05），hsCRP 和血清黏蛋白与 REE 呈正相关（P<0.01），而触珠蛋白与 PAEE 呈负相关（P<0.05）。在同时检测能量消耗各组成部分与炎症标志物的相关性的逐步回归分析中，PAEE 仍然是 hsCRP 和触珠蛋白的唯一预测因子（P<0.05），分别解释了其变异的 14%和 5%，而 REE 是血清黏蛋白的唯一预测因子（r （2）=0.05，P=0.02），调整脂肪量后。将瘦素加入回归模型中，炎症标志物与能量消耗各组成部分之间的关系相似。
PAEE 是久坐超重/肥胖绝经后女性慢性疾病患者 hsCRP 和触珠蛋白的独立预测因子。我们的数据支持身体活动在降低亚临床炎症和代谢性及心血管疾病风险方面的作用。
