Vella Chantal A, Allison Matthew A, Cushman Mary, Jenny Nancy S, Miles Mary P, Larsen Britta, Lakoski Susan G, Michos Erin D, Blaha Michael J
1Department of Movement Sciences, University of Idaho, Moscow, ID; 2Department of Family and Preventive Medicine, University of California San Diego, San Diego, CA; 3Department of Medicine, Hematology/Oncology Division, University of Vermont, Colchester, VT; 4Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, VT; 5Department of Health and Human Development, Montana State University, Bozeman, MT; 6Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX; and 7Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD.
Med Sci Sports Exerc. 2017 May;49(5):915-921. doi: 10.1249/MSS.0000000000001179.
Physical activity is associated with decreased adiposity-related inflammation in adults. Whether this association is independent of central obesity is unknown but important for understanding the mechanisms associated with reducing cardiometabolic disease risk through physical activity. This study examined whether associations of physical activity and obesity-related inflammatory markers were independent of central adiposity.
Between 2002 and 2005, 1970 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history and physical activity questionnaires, underwent physical measurements including computed tomography to quantify abdominal visceral and subcutaneous fat, and measurements of adiponectin, leptin, interleukin-6, tumor necrosis factor-alpha, and resistin. Statistical analyses included analysis of covariance and multivariable-adjusted regression.
The mean (range) age of participants was 64.7 (55-84) yr and 50% were women. After adjustment for age and sex, and compared with the lowest quartile, inflammatory markers in the highest quartile of moderate-to-vigorous physical activity were 16% higher for adiponectin and 30%, 26%, and 9% lower for leptin, interleukin-6, and resistin, respectively (P < 0.05 for all). In linear regression adjusted for demographics, dyslipidemia, hypertension, diabetes, smoking, glomerular filtration rate, renin, and aldosterone, each standard deviation increment of moderate-to-vigorous physical activity was associated with significantly higher levels of adiponectin (β = 0.04) and lower levels of leptin (β = -0.06), interleukin-6 (β = -0.08), and resistin (β = -0.05, P < 0.05 for all). The associations with leptin, interleukin-6, and resistin were independent of total and central adiposity (P < 0.05), whereas the association between moderate-to-vigorous physical activity and adiponectin was attenuated by central adiposity (P > 0.05). There were no significant interactions by race/ethnicity or sex.
Moderate-to-vigorous physical activity was associated with a more favorable profile of inflammatory markers, independent of relevant cardiometabolic disease risk factors including central obesity.
身体活动与成年人肥胖相关炎症的减轻有关。这种关联是否独立于中心性肥胖尚不清楚，但对于理解通过身体活动降低心血管代谢疾病风险的相关机制很重要。本研究调查了身体活动与肥胖相关炎症标志物的关联是否独立于中心性肥胖。
2002年至2005年期间，来自动脉粥样硬化多民族研究的1970名参与者完成了详细的健康史和身体活动问卷，接受了包括计算机断层扫描在内的身体测量以量化腹部内脏和皮下脂肪，并测量了脂联素、瘦素、白细胞介素-6、肿瘤坏死因子-α和抵抗素。统计分析包括协方差分析和多变量调整回归。
参与者的平均（范围）年龄为64.7（55 - 84）岁，50%为女性。在调整年龄和性别后，与最低四分位数相比，中度至剧烈身体活动最高四分位数中的炎症标志物，脂联素高16%，而瘦素、白细胞介素-6和抵抗素分别低30%、26%和9%（所有P < 0.05）。在针对人口统计学、血脂异常、高血压、糖尿病、吸烟、肾小球滤过率、肾素和醛固酮进行调整的线性回归中，中度至剧烈身体活动的每增加一个标准差，脂联素水平显著升高（β = 0.04），而瘦素（β = -0.06）、白细胞介素-6（β = -0.08）和抵抗素（β = -0.05，所有P < 0.05）水平降低。与瘦素、白细胞介素-6和抵抗素的关联独立于总体和中心性肥胖（P < 0.05），而中度至剧烈身体活动与脂联素之间的关联因中心性肥胖而减弱（P > 0.05）。种族/民族或性别之间没有显著的相互作用。
中度至剧烈身体活动与更有利的炎症标志物谱相关，独立于包括中心性肥胖在内的相关心血管代谢疾病风险因素。
