Garg S K, Chase H P, Jackson W E, Harris S, Marshall G, Hoops S
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262.
Diabetes Res Clin Pract. 1991 Mar;11(3):189-93. doi: 10.1016/s0168-8227(05)80032-4.
The association of retinal changes with exercise microalbuminuria and with changes in systolic and diastolic blood pressure (BP) were evaluated in 162 young subjects with insulin-dependent (type 1) diabetes mellitus. Higher systolic and diastolic BPs at rest or after 10 or 20 min of exercise were significantly associated with more severe retinal changes in the subjects with diabetes compared to controls (P less than 0.02; global ANOVA). The mean (+/- SEM) exercise albumin excretion rate (AER) was 17.6 +/- 3.1 if there was no evidence of retinopathy compared to 81.5 +/- 23.5 when only microaneurysms were detected and 467.1 +/- 133.3 when more severe retinopathy was present. The percentage of subjects with abnormal AERs for these three retinal groups was 13, 30 and 60, respectively. (P less than 0.0001, chi-square test). It is clear that retinal changes relate to early renal changes, as monitored by exercise AERs and changes in resting and exercise BPs. It is concluded that the renal and retinal microvascular changes occur concurrently in young subjects with type 1 diabetes.
在162名胰岛素依赖型（1型）糖尿病年轻受试者中，评估了视网膜病变与运动性微量白蛋白尿以及收缩压和舒张压（BP）变化之间的关联。与对照组相比，糖尿病受试者静息时或运动10或20分钟后的收缩压和舒张压升高与更严重的视网膜病变显著相关（P<0.02；全局方差分析）。如果没有视网膜病变的证据，平均（±SEM）运动白蛋白排泄率（AER）为17.6±3.1，而仅检测到微动脉瘤时为81.5±23.5，存在更严重的视网膜病变时为467.1±133.3。这三个视网膜组中AER异常的受试者百分比分别为13%、30%和60%。（P<0.0001，卡方检验）。显然，视网膜病变与早期肾脏病变有关，通过运动AER以及静息和运动BP的变化来监测。得出的结论是，1型糖尿病年轻受试者的肾脏和视网膜微血管病变同时发生。
