Department of Radiotherapy Oncology, the 1st Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
BMC Cancer. 2010 Apr 8;10:131. doi: 10.1186/1471-2407-10-131.
The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for nodal metastasis and survival, we studied peritumoral LVD (P-LVD) and intratumoral LVD (I-LVD) in samples from 102 patients with endometrial carcinoma;
Endometrial carcinoma tissues were analyzed for lymphatic vessels by immunohistochemical staining with an antibody against LYVE-1. Univariate analysis was performed with Kaplan-Meier life-table curves to estimate survival, and was compared using the log rank test. Prognostic models used multivariate Cox regression analysis for multivariate analyses of survival;
Our study showed that P-LVD, but not I-LVD, was significantly correlated with lymph vascular space invasion (LVSI), lymph node metastasis, tumor stage, and CD44 expression in endometrial carcinoma. Moreover, P-LVD was an independent prognostic factor for progression-free survival and overall survival of endometrial carcinoma;
P-LVD may serve as a prognostic factor for endometrial carcinoma. The peritumoral lymphatics might play an important role in lymphatic vessel metastasis.
淋巴系统是癌细胞扩散的主要途径，也是抗肿瘤治疗的潜在靶点。为了研究淋巴管密度（LVD）增加是否是淋巴结转移和生存的预后因素，我们研究了 102 例子宫内膜癌患者肿瘤周围 LVD（P-LVD）和肿瘤内 LVD（I-LVD）。
用抗 LYVE-1 抗体的免疫组织化学染色分析子宫内膜癌组织中的淋巴管。采用 Kaplan-Meier 生命表曲线进行单因素分析以估计生存，并使用对数秩检验进行比较。使用多变量 Cox 回归分析进行多变量分析生存的预后模型。
我们的研究表明，P-LVD 而不是 I-LVD 与子宫内膜癌中的淋巴管侵犯（LVSI）、淋巴结转移、肿瘤分期和 CD44 表达显著相关。此外，P-LVD 是子宫内膜癌无进展生存和总生存的独立预后因素。
P-LVD 可能是子宫内膜癌的预后因素。肿瘤周围的淋巴管可能在淋巴管转移中起重要作用。
