Wörheide J, Bonsmann G, Kolde G, Hamm H
Zentrum für Dermatologie, Westfälischen Wilhelms-Universität Münster.
Hautarzt. 1991 Feb;42(2):112-5.
Reports of cancer development in lichen planus mostly concern the oral erosive form. The reported frequency of malignant transformation ranges between less than 1% and 10%. There have been a few isolated observations of malignant transformation of cutaneous lichen planus. In these cases, the hypertrophic type located on the lower limbs predominated. We report an unusual case of squamous cell carcinoma developing on the glans penis in the presence of hypertrophic lichen planus. Systemic treatment of the lichen planus with dapsone, retinoids, corticosteroids and topical cyclosporin A failed to prevent this development.
扁平苔藓发生癌变的报道大多涉及口腔糜烂型。报道的恶性转化频率在不到1%至10%之间。有一些关于皮肤扁平苔藓恶性转化的孤立观察病例。在这些病例中，以下肢为主的肥厚型最为常见。我们报告一例在肥厚性扁平苔藓基础上阴茎头发生鳞状细胞癌的罕见病例。使用氨苯砜、维甲酸、皮质类固醇和外用环孢素A对扁平苔藓进行全身治疗未能阻止这种情况的发生。
