Schirren C G, Schmoeckel C
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1992 Nov;43(11):707-10.
A 51-year-old patient presented with aggregated papules and with a central, partly erosive plaque on the left lower leg. Histological examination revealed hypertrophic lichen planus peripherally and a verrucous carcinoma within the centre. The lesion was removed surgically. Shortly after wards an atrophic lichen planus developed exclusively within the skin graft, which was effectively treated with topical steroid cream. The patient remained disease-free for 2 years. The literature relating to malignant transformation of cutaneous lichen planus was reviewed. In most cases, as in the present one, the hypertrophic form of lichen planus and the verrucous type of carcinoma (Ackerman) are reported. Recent investigations have revealed human papilloma virus types 6 and 11 within such lesions.
一名51岁患者左小腿出现丘疹聚集，并伴有中央部分糜烂的斑块。组织学检查显示外周为肥厚性扁平苔藓，中央为疣状癌。病变通过手术切除。术后不久，仅在皮肤移植部位出现萎缩性扁平苔藓，外用类固醇乳膏有效治疗。患者2年无病。回顾了与皮肤扁平苔藓恶变相关的文献。在大多数情况下，如本例，报告的是肥厚型扁平苔藓和疣状癌（阿克曼型）。最近的研究在这类病变中发现了6型和11型人乳头瘤病毒。
