Krasowska Dorota, Kozłowicz Katarzyna, Kowal Małgorzata, Kurylcio Andrzej, Budzyńska-Włodarczyk Jolanta, Polkowski Wojciech, Chodorowska Grażyna
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University, Lublin, Poland.
Ann Agric Environ Med. 2012;19(4):787-9.
Lichen planus is a chronic mucocutaneous T-cell-mediated disease, the cause of which remains unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. The presented study concerns the case of a 62-year-old woman in whom twice malignant transformation of hypertrophic lichen planus in the dorsal part of the left foot developed. Several studies have pointed out the malignant transformation potential of lichen planus. Epidemiological studies from the last 20 years have revealed a malignant transformation rate of 0.27% per year, emphasizing the importance of the clinical follow-up of lichen planus patients.
扁平苔藓是一种慢性皮肤黏膜T细胞介导的疾病，其病因尚不清楚。1903年报道了首例扁平苔藓转化为鳞状细胞癌的病例。本研究涉及一名62岁女性，其左脚背部肥厚性扁平苔藓发生了两次恶变。多项研究指出了扁平苔藓的恶变潜能。过去20年的流行病学研究显示，每年的恶变率为0.27%，强调了对扁平苔藓患者进行临床随访的重要性。
