Chen L S, Kaphingst K A
Department of Health and Kinesiology, Texas A&M University, College Station, TX 77843-4243, USA.
Public Health Genomics. 2011;14(1):26-34. doi: 10.1159/000294151. Epub 2010 Apr 8.
Individuals with a family history of lung cancer have a two- to threefold increased risk for developing this disease. Family history information may be useful in lung cancer prevention and control approaches, but research is needed regarding how individuals interpret this information. This study examined associations between lung cancer family history and individuals' risk perceptions, based on smoking status.
Data were analyzed from 5,105 U.S. adult respondents to the 2005 Health Information National Trends Survey, which was conducted with a nationally representative sample.
In multivariate models, family history of lung cancer was positively associated with absolute and relative risk perceptions among all respondents (β=0.60, 95% CI=0.33-0.87 and β=0.17, 95% CI=0.04-0.31, respectively) and among never smokers (β=0.40, 95% CI=0.14-0.67 and β=0.14, 95% CI=0.01-0.27, respectively). However, these associations were not significant for current and former smokers.
While perceived risk was associated with family history of lung cancer among never smokers, this was not true for other smoking status subgroups. Therefore, former and current smokers might not respond as intended to cancer prevention or cessation messages tailored based on family history. The results suggest directions for future research into how to best integrate family history information into prevention and control efforts.
有肺癌家族史的个体患此病的风险增加两到三倍。家族史信息可能有助于肺癌的预防和控制，但需要研究个体如何解读这些信息。本研究基于吸烟状况，考察了肺癌家族史与个体风险认知之间的关联。
对来自2005年健康信息全国趋势调查的5105名美国成年受访者的数据进行分析，该调查采用了具有全国代表性的样本。
在多变量模型中，肺癌家族史与所有受访者（β=0.60，95%置信区间=0.33-0.87和β=0.17，95%置信区间=0.04-0.31）以及从不吸烟者（β=0.40，95%置信区间=0.14-0.67和β=0.14，95%置信区间=0.01-0.27）的绝对和相对风险认知呈正相关。然而，对于当前吸烟者和既往吸烟者，这些关联并不显著。
虽然从不吸烟者的感知风险与肺癌家族史有关，但其他吸烟状况亚组并非如此。因此，既往吸烟者和当前吸烟者可能不会按预期对基于家族史定制的癌症预防或戒烟信息做出反应。研究结果为未来如何将家族史信息最佳地整合到预防和控制工作中指明了方向。
