Infection Immunology Research Group, Department of Microbial Pathogenesis, HZI - Helmholtz Center for Infection Research, Braunschweig, Germany.
J Innate Immun. 2009;1(3):176-80. doi: 10.1159/000203699. Epub 2009 Feb 20.
Recent investigations have highlighted new roles for neutrophils in the biology of infection and inflammation. Neutrophils are one of the main players in the innate immune system and actively contribute to host defense by killing pathogens. Added to their ability to eliminate microorganisms by phagocytosis, neutrophils can also kill microbes by capturing them in extracellular structures consisting of granule proteins and DNA called neutrophil extracellular traps (NETs). This review summarizes the recent advancements regarding the structure, production and biological relevance of NETs.
最近的研究强调了中性粒细胞在感染和炎症生物学中的新作用。中性粒细胞是先天免疫系统的主要参与者之一，通过杀死病原体积极促进宿主防御。除了通过吞噬作用消除微生物的能力外，中性粒细胞还可以通过捕获由颗粒蛋白和称为中性粒细胞胞外陷阱 (NETs) 的 DNA 组成的细胞外结构中的微生物来杀死微生物。这篇综述总结了关于 NETs 的结构、产生和生物学相关性的最新进展。
