Agarwal Nupur, Kumar Veerendra S C, Gujjari Sheela A
PG Student, Department of Periodontics, J.S.S. Dental College & Hospital, Mysore, India.
J Indian Soc Periodontol. 2009 Jan;13(1):6-11. doi: 10.4103/0972-124X.51887.
Anemia of chronic disease (ACD) is one of the most common forms of anemia. It is defined as anemia occurring in chronic infections, inflammatory conditions or neoplastic disorders which are not due to marrow deficiencies or other diseases, and occurring despite the presence of adequate iron stores and vitamins. Periodontitis is one of the most prevalent chronic inflammatory diseases in humans. This study aimed at finding out if periodontitis, like other inflammatory conditions, could lead to anemia.
Thirty chronic generalized periodontitis male patients with hemoglobin levels below 15 mg/dl and serum ferritin values above 30 ng/ml were selected. The various blood parameters recorded at baseline were hemoglobin levels(Hb), erythrocyte count (RBC), erythrocyte sedimentation rate (ESR), mean corpuscular volume(MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). PERIODONTAL PARAMETERS RECORDED AT BASELINE INCLUDED: plaque index, gingival index, probing pocket depth, clinical attachment level. Periodontal treatment including surgery if required was carried out in all the patients. Periodontal status of patients was monitored by repeating evaluation of periodontal indices at three months and at the end of one year. The hematological values were again measured at the end of one year.
The results showed that correction of periodontal inflammation resulted in a significant increase in hemoglobin levels and erythrocyte counts. The erythrocyte sedimentation rate showed a reduction indicating resolution of periodontal inflammation. There was a significant, but much lesser, improvement in MCV, MCH and MCHC values.
The results of this study showed that treatment of periodontitis leads to an improvement in hematocrit and other related blood parameters in chronic generalized periodontitis patients with anemia. This provides evidence that periodontitis like other chronic diseases may also cause anemia.
慢性病性贫血(ACD)是最常见的贫血形式之一。它被定义为在慢性感染、炎症性疾病或肿瘤性疾病中发生的贫血,并非由于骨髓缺乏或其他疾病引起,且尽管存在足够的铁储备和维生素仍会发生。牙周炎是人类最普遍的慢性炎症性疾病之一。本研究旨在探究牙周炎是否像其他炎症性疾病一样会导致贫血。
选取30名血红蛋白水平低于15mg/dl且血清铁蛋白值高于30ng/ml的慢性广泛性牙周炎男性患者。记录的基线血液参数包括血红蛋白水平(Hb)、红细胞计数(RBC)、红细胞沉降率(ESR)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)和平均红细胞血红蛋白浓度(MCHC)。基线记录的牙周参数包括:菌斑指数、牙龈指数、探诊深度、临床附着水平。所有患者均接受牙周治疗,必要时包括手术。通过在三个月和一年结束时重复评估牙周指数来监测患者的牙周状况。一年结束时再次测量血液学值。
结果显示,牙周炎症的改善导致血红蛋白水平和红细胞计数显著增加。红细胞沉降率降低表明牙周炎症得到缓解。MCV、MCH和MCHC值有显著但较小的改善。
本研究结果表明,治疗牙周炎可使贫血的慢性广泛性牙周炎患者的血细胞比容和其他相关血液参数得到改善。这提供了证据表明牙周炎像其他慢性疾病一样也可能导致贫血。