Hutter J W, van der Velden U, Varoufaki A, Huffels R A, Hoek F J, Loos B G
Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
J Clin Periodontol. 2001 Oct;28(10):930-6. doi: 10.1034/j.1600-051x.2001.028010930.x.
Anemia of chronic disease (ACD) is defined as the anemia occurring in chronic infections and inflammatory conditions, that is not due to marrow deficiencies or other diseases and in the presence of adequate iron stores and vitamins. The purpose of the present study was to investigate whether periodontitis patients show signs of anemia.
39 patients with severe periodontitis, 71 patients with moderate periodontitis and 42 controls, all with good general health, participated in this study. The mean age of all groups was 42 years. Several red blood cell parameters were determined from peripheral blood samples.
Overall data analysis indicated that periodontitis patients have a lower hematocrit, lower numbers of erythrocytes, lower hemoglobin levels and higher erythrocyte sedimentation rates. These results were adjusted for the following possible confounders: gender, age, smoking, ethnicity and level of education. Further, more periodontitis patients (23%) than controls (7%), had hemoglobin levels below the normal reference range.
The present study provides further evidence that periodontitis has systemic effects and that periodontitis may tend towards anemia. This phenomenon may be explained by a depressed erythropoiesis.
慢性病贫血（ACD）被定义为发生于慢性感染和炎症性疾病中的贫血，并非由骨髓缺陷或其他疾病引起，且存在充足的铁储备和维生素。本研究的目的是调查牙周炎患者是否有贫血迹象。
39例重度牙周炎患者、71例中度牙周炎患者和42名对照者参与了本研究，所有参与者总体健康状况良好。所有组的平均年龄为42岁。从外周血样本中测定了几个红细胞参数。
总体数据分析表明，牙周炎患者的血细胞比容较低、红细胞数量较少、血红蛋白水平较低且红细胞沉降率较高。这些结果针对以下可能的混杂因素进行了校正：性别、年龄、吸烟、种族和教育程度。此外，血红蛋白水平低于正常参考范围的牙周炎患者（23%）多于对照者（7%）。
本研究提供了进一步的证据，表明牙周炎具有全身影响，且牙周炎可能倾向于导致贫血。这种现象可能由红细胞生成受抑制来解释。
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