Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic.
Microbiol Immunol. 2010 Apr;54(4):237-45. doi: 10.1111/j.1348-0421.2010.00198.x.
Pathogenic bacteria have developed various mechanisms to evade host immune defense systems. Invasion of pathogenic bacteria requires interaction of the pathogen with host receptors, followed by activation of signal transduction pathways and rearrangement of the cytoskeleton to facilitate bacterial entry. Numerous bacteria exploit specialized plasma membrane microdomains, commonly called membrane rafts, which are rich in cholesterol, sphingolipids and a special set of signaling molecules which allow entry to host cells and establishment of a protected niche within the host. This review focuses on the current understanding of the raft hypothesis and the means by which pathogenic bacteria subvert membrane microdomains to promote infection.
病原菌已经发展出各种机制来逃避宿主的免疫防御系统。病原菌的入侵需要病原体与宿主受体相互作用，然后激活信号转导途径并重新排列细胞骨架，以促进细菌进入。许多细菌利用专门的质膜微域，通常称为膜筏，这些微域富含胆固醇、鞘脂和一组特殊的信号分子，使它们能够进入宿主细胞并在宿主内部建立一个受保护的小生境。这篇综述重点介绍了目前对筏假说的理解，以及病原菌破坏质膜微域以促进感染的方式。
