Mañes Santos, del Real Gustavo, Martínez-A Carlos
Department of Immunology and Oncology, Centro Nacional de Biotecnología/Spanish Council for Scientific Research, Campus de la Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain.
Nat Rev Immunol. 2003 Jul;3(7):557-68. doi: 10.1038/nri1129.
Throughout evolution, organisms have developed immune-surveillance networks to protect themselves from potential pathogens. At the cellular level, the signalling events that regulate these defensive responses take place in membrane rafts--dynamic microdomains that are enriched in cholesterol and glycosphingolipids--that facilitate many protein-protein and lipid-protein interactions at the cell surface. Pathogens have evolved many strategies to ensure their own survival and to evade the host immune system, in some cases by hijacking rafts. However, understanding the means by which pathogens exploit rafts might lead to new therapeutic strategies to prevent or alleviate certain infectious diseases, such as those caused by HIV-1 or Ebola virus.
在整个进化过程中，生物体形成了免疫监视网络来保护自身免受潜在病原体的侵害。在细胞水平上，调节这些防御反应的信号事件发生在膜筏中——富含胆固醇和糖鞘脂的动态微区——它促进了细胞表面许多蛋白质-蛋白质和脂质-蛋白质的相互作用。病原体已经进化出许多策略来确保自身存活并逃避宿主免疫系统，在某些情况下是通过劫持膜筏。然而，了解病原体利用膜筏的方式可能会带来预防或减轻某些传染病（如由HIV-1或埃博拉病毒引起的疾病）的新治疗策略。
