Lafont Frank, Abrami Laurence, van der Goot F Gisou
Department of Genetics and Microbiology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.
Curr Opin Microbiol. 2004 Feb;7(1):4-10. doi: 10.1016/j.mib.2003.12.007.
Bacteria rely on numerous basic cellular functions of their target cells to reach successful infection. The recent discovery that the plasma membrane contains specialized microdomains, called lipid rafts, with many specific functions but in particular with the ability to concentrate signaling molecules, has therefore attracted the attention of cellular microbiologists. Since then an increasing number of bacteria and their products have been shown to interact with lipid rafts to promote infection or intoxication. Here we review why certain bacteria and/or their products are attracted toward these lipid microdomains.
细菌依靠靶细胞的众多基本细胞功能来实现成功感染。质膜含有称为脂筏的特殊微结构域，具有许多特定功能，特别是具有浓缩信号分子的能力，这一最新发现因此引起了细胞微生物学家的关注。从那时起，越来越多的细菌及其产物已被证明与脂筏相互作用以促进感染或中毒。在这里，我们综述了某些细菌和/或其产物被吸引到这些脂质微结构域的原因。
