Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Infection. 2019 Feb;47(1):13-23. doi: 10.1007/s15010-018-1222-5. Epub 2018 Oct 1.
Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies.
All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines.
Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases.
Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.
细菌感染是世界范围内发病率和死亡率的首要原因。治疗细菌感染的常见策略是局部或全身使用抗菌药物。目前，抗生素耐药性的增加是一个严重且全球性的问题。由于感染的最重要因素是细菌附着在宿主细胞上，因此，干扰细菌附着到宿主组织或在感染早期将其从组织上分离的新技术和有吸引力的方法是很好的治疗策略。
使用搜索关键字搜索了所有可用的国家和国际数据库。在这里，我们综述了各种抗黏附治疗方法，包括受体和黏附模拟物、膳食成分、亚致死浓度的抗生素和基于黏附的疫苗的使用。
总的来说，这些发现表明，干扰细菌黏附可以作为一种新的手段来对抗传染病。
基于抗黏附的治疗方法可有效预防和治疗细菌感染，但需要进一步研究以阐明其潜在机制。
