Rheumatology Division, Federal University, Santa Catarina, Florianópolis-SC, Brazil.
Joint Bone Spine. 2010 May;77(3):229-31. doi: 10.1016/j.jbspin.2010.02.011. Epub 2010 Apr 7.
To investigate the lipoprotein profile of patients with primary Sjögren's syndrome (pSS) and its association with laboratory tests, including markers of inflammation.
This is a cross-sectional study among patients with pSS and healthy controls. We analyzed the lipoprotein profile of 73 pSS patients compared to 65 healthy individuals in the control group. We further evaluated possible associations between dyslipidemia in pSS patients and laboratory parameters including: hypergammaglobulinemia, autoantibodies [antinuclear antibodies (ANA), rheumatoid factor (RF), anti-Ro, anti-La], and acute-phase reactants [C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)].
Patients and controls were comparable regarding the demographic variables. Lipoprotein profile was similar between pSS patients and controls: total cholesterol (204.0+/-43.39 versus 206.5+/-42.76 mg/mL, P=0.73), LDL fraction (131.6+/-37.38 versus 130.62+/-38.24 mg/dL, P=0.88) and HDL fraction (49.7+/-13.5 versus 51+/-11.5mg/dL, P=0.56), triglycerides (129.3+/-81.0 versus 116.8+/-53.5mg/dL, P=0.29). However, patients with pSS had a strong trend to present dyslipidemia when compared to healthy individuals (76.7% versus 61.5%, P=0.06). The presence of dyslipidemia in pSS was associated with increased ESR (44.05+/-28.07 versus 28.28+/-18.00, P=0.03), but not with other laboratory markers of the disease and inflammation.
DISCUSSION/CONCLUSION: pSS patients frequently present abnormal lipid profile, which are associated with higher levels of ESR. Thus, similar to other systemic inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), lipid profile should be evaluated in pSS patients, with the aim of initiating specific therapeutic strategy for prevention of cardiovascular events.
研究原发性干燥综合征（pSS）患者的脂蛋白谱及其与实验室检查的关系，包括炎症标志物。
这是一项 pSS 患者与健康对照者的横断面研究。我们分析了 73 例 pSS 患者与 65 例健康对照者的脂蛋白谱。我们进一步评估了 pSS 患者的血脂异常与实验室参数之间的可能相关性，包括：高丙种球蛋白血症、自身抗体[抗核抗体（ANA）、类风湿因子（RF）、抗 Ro、抗 La]和急性期反应物[C 反应蛋白（CRP）和红细胞沉降率（ESR）]。
患者和对照组在人口统计学变量方面具有可比性。pSS 患者和对照组的脂蛋白谱相似：总胆固醇（204.0+/-43.39 与 206.5+/-42.76mg/dL，P=0.73）、LDL 部分（131.6+/-37.38 与 130.62+/-38.24mg/dL，P=0.88）和 HDL 部分（49.7+/-13.5 与 51+/-11.5mg/dL，P=0.56）、甘油三酯（129.3+/-81.0 与 116.8+/-53.5mg/dL，P=0.29）。然而，与健康个体相比，pSS 患者有发生血脂异常的强烈趋势（76.7%比 61.5%，P=0.06）。pSS 患者血脂异常与 ESR 升高有关（44.05+/-28.07 与 28.28+/-18.00，P=0.03），但与疾病和炎症的其他实验室标志物无关。
讨论/结论：pSS 患者常出现异常的脂质谱，与更高的 ESR 水平相关。因此，与其他系统性炎症性疾病（如类风湿关节炎[RA]和系统性红斑狼疮[SLE]）一样，pSS 患者的脂质谱应进行评估，以制定预防心血管事件的特定治疗策略。
