• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新型血清代谢组学panel 可区分 IgG4 相关硬化性胆管炎与原发性硬化性胆管炎。

A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.

机构信息

Department of Pharmacology, University of Oxford, Oxford, UK.

Department of Chemistry, University of Oxford, Oxford, UK.

出版信息

Liver Int. 2022 Jun;42(6):1344-1354. doi: 10.1111/liv.15192. Epub 2022 Feb 21.

DOI:10.1111/liv.15192
PMID:35129255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9546203/
Abstract

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) and IgG4-related sclerosing cholangitis (IgG4-SC) are chronic fibro-inflammatory immune-mediated hepatobiliary conditions that are challenging to distinguish in a clinical setting. Accurate non-invasive biomarkers for discriminating PSC and IgG4-SC are important to ensure a correct diagnosis, prompt therapy and adequate cancer surveillance.

METHODS

We performed nuclear magnetic resonance (NMR)-based metabolomic profiling using serum samples collected prospectively from patients with PSC (n = 100), IgG4-SC (n = 23) and healthy controls (HC; n = 16).

RESULTS

Multivariate analysis of the serum metabolome discriminated PSC from IgG4-SC with greater accuracy (AUC 0.95 [95%CI 0.90-0.98]) than IgG4 titre (AUC 0.87 [95%CI 0.79-0.94]). When inflammatory bowel disease (IBD) was excluded as a comorbid condition (IgG4-SC n = 20, PSC n = 22), the diagnostic AUC increased to 1.0, suggesting that the metabolome differences identified are not a result of the increased prevalence of IBD in PSC relative to IgG4-SC patients. Serum lactate (p < .0001), glucose (p < .01) and glutamine (p < .01) metabolites were increased in IgG4-related disease (IgG4-RD) and IgG4-SC individuals compared to PSC, whereas mobile choline (p < .05), 3-hydroxybutyric acid (p < .01) and -CH lipoprotein resonances (p < .01) were decreased.

CONCLUSIONS

Taken together, serum metabolomic profiling has the potential to be incorporated as a diagnostic criterion, independent of IgG4 titre, to improve the diagnosis of IgG4-RD and help distinguish IgG4-SC from PSC.

摘要

背景与目的

原发性硬化性胆管炎（PSC）和 IgG4 相关硬化性胆管炎（IgG4-SC）是慢性纤维炎症性免疫介导的肝胆疾病，在临床环境中难以区分。准确的非侵入性生物标志物对于区分 PSC 和 IgG4-SC 非常重要，可以确保正确的诊断、及时的治疗和充分的癌症监测。

方法

我们使用前瞻性收集的 PSC（n=100）、IgG4-SC（n=23）和健康对照者（HC；n=16）的血清样本进行基于核磁共振（NMR）的代谢组学分析。

结果

对血清代谢组的多变量分析能够更准确地区分 PSC 和 IgG4-SC（AUC 0.95 [95%CI 0.90-0.98]），优于 IgG4 滴度（AUC 0.87 [95%CI 0.79-0.94]）。当排除炎症性肠病（IBD）作为合并症（IgG4-SC n=20，PSC n=22）时，诊断 AUC 增加到 1.0，表明所鉴定的代谢组差异不是由于 PSC 患者中 IBD 的患病率高于 IgG4-SC 患者所致。与 PSC 相比，IgG4 相关疾病（IgG4-RD）和 IgG4-SC 个体的血清乳酸盐（p<0.0001）、葡萄糖（p<0.01）和谷氨酰胺（p<0.01）代谢物升高，而移动胆碱（p<0.05）、3-羟基丁酸（p<0.01）和-CH 脂蛋白共振（p<0.01）降低。

结论

综上所述，血清代谢组学分析有可能被纳入诊断标准，独立于 IgG4 滴度，以改善 IgG4-RD 的诊断，并有助于区分 IgG4-SC 和 PSC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/f1286cbb3d72/LIV-42-1344-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/92ed0a0f1a81/LIV-42-1344-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/ec13b3ecf849/LIV-42-1344-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/a7e3c42946cc/LIV-42-1344-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/37c66ff28cae/LIV-42-1344-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/641cf15265bc/LIV-42-1344-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/f1286cbb3d72/LIV-42-1344-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/92ed0a0f1a81/LIV-42-1344-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/ec13b3ecf849/LIV-42-1344-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/a7e3c42946cc/LIV-42-1344-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/37c66ff28cae/LIV-42-1344-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/641cf15265bc/LIV-42-1344-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b22/9546203/f1286cbb3d72/LIV-42-1344-g002.jpg

相似文献

1
A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.一种新型血清代谢组学panel 可区分 IgG4 相关硬化性胆管炎与原发性硬化性胆管炎。
Liver Int. 2022 Jun;42(6):1344-1354. doi: 10.1111/liv.15192. Epub 2022 Feb 21.
2
Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis.IgG4 相关硬化性胆管炎和原发性硬化性胆管炎的粪便微生物组和代谢组改变。
Gut. 2022 May;71(5):899-909. doi: 10.1136/gutjnl-2020-323565. Epub 2021 May 25.
3
Inflammatory bowel disease of primary sclerosing cholangitis: a distinct entity?原发性硬化性胆管炎的炎症性肠病：一种独特的疾病实体？
World J Gastroenterol. 2014 Mar 28;20(12):3245-54. doi: 10.3748/wjg.v20.i12.3245.
4
The long-term outcomes of patients with immunoglobulin G4-related sclerosing cholangitis: the Mayo Clinic experience.免疫球蛋白G4相关性硬化性胆管炎患者的长期预后：梅奥诊所的经验
J Gastroenterol. 2020 Nov;55(11):1087-1097. doi: 10.1007/s00535-020-01714-7. Epub 2020 Aug 8.
5
IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis.IgG4 相关硬化性胆管炎与原发性硬化性胆管炎。
Gut Liver. 2019 May 15;13(3):300-307. doi: 10.5009/gnl18085.
6
Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis.CCL1-CCR8 相互作用可能参与 IgG4 相关硬化性胆管炎中的淋巴细胞募集。
J Hepatol. 2013 Nov;59(5):1059-64. doi: 10.1016/j.jhep.2013.06.016. Epub 2013 Jun 25.
7
Development of a scoring system for differentiating IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.一种用于鉴别IgG4相关性硬化性胆管炎与原发性硬化性胆管炎的评分系统的开发。
J Gastroenterol. 2017 Apr;52(4):483-493. doi: 10.1007/s00535-016-1246-5. Epub 2016 Jul 28.
8
Review of primary sclerosing cholangitis with increased IgG4 levels.IgG4水平升高的原发性硬化性胆管炎综述
World J Gastroenterol. 2020 Jun 21;26(23):3126-3144. doi: 10.3748/wjg.v26.i23.3126.
9
Nationwide survey for primary sclerosing cholangitis and IgG4-related sclerosing cholangitis in Japan.日本原发性硬化性胆管炎和IgG4相关性硬化性胆管炎的全国性调查。
J Hepatobiliary Pancreat Sci. 2014 Jan;21(1):43-50. doi: 10.1002/jhbp.50. Epub 2013 Oct 29.
10
Clinical Utility of Personalized Serum IgG Subclass Ratios for the Differentiation of IgG4-Related Sclerosing Cholangitis (IgG4-SC) from Primary Sclerosing Cholangitis (PSC) and Cholangiocarcinoma (CCA).个性化血清IgG亚类比值在鉴别IgG4相关性硬化性胆管炎（IgG4-SC）与原发性硬化性胆管炎（PSC）及胆管癌（CCA）中的临床应用
J Pers Med. 2022 May 24;12(6):855. doi: 10.3390/jpm12060855.

引用本文的文献

1
IgG4-Related Cholangitis.IgG4相关性胆管炎
Semin Liver Dis. 2025 Sep;45(3):381-396. doi: 10.1055/a-2588-3875. Epub 2025 May 8.
2
Omics in IgG4-related disease.IgG4相关疾病中的组学
Chin Med J (Engl). 2024 Oct 25. doi: 10.1097/CM9.0000000000003320.
3
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis.原发性硬化性胆管炎患者血清样本中独特的代谢组学和脂质组学特征。

本文引用的文献

1
Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis.IgG4 相关硬化性胆管炎和原发性硬化性胆管炎的粪便微生物组和代谢组改变。
Gut. 2022 May;71(5):899-909. doi: 10.1136/gutjnl-2020-323565. Epub 2021 May 25.
2
UPLC-MS based plasma metabolomics and lipidomics reveal alterations associated with IgG4-related disease.基于 UPLC-MS 的血浆代谢组学和脂质组学揭示与 IgG4 相关疾病相关的改变。
Rheumatology (Oxford). 2021 Jul 1;60(7):3252-3261. doi: 10.1093/rheumatology/keaa775.
3
Review of primary sclerosing cholangitis with increased IgG4 levels.
Front Med (Lausanne). 2024 Jun 4;11:1334865. doi: 10.3389/fmed.2024.1334865. eCollection 2024.
4
Liver transplant in patients with primary sclerosing cholangitis: A retrospective cohort from Northeastern Brazil.原发性硬化性胆管炎患者的肝移植：来自巴西东北部的一项回顾性队列研究。
World J Hepatol. 2023 Sep 27;15(9):1033-1042. doi: 10.4254/wjh.v15.i9.1033.
5
Inflammasome and pyroptosis in autoimmune liver diseases.自身免疫性肝病中的炎性小体与细胞焦亡。
Front Immunol. 2023 Mar 8;14:1150879. doi: 10.3389/fimmu.2023.1150879. eCollection 2023.
IgG4水平升高的原发性硬化性胆管炎综述
World J Gastroenterol. 2020 Jun 21;26(23):3126-3144. doi: 10.3748/wjg.v26.i23.3126.
4
Immune metabolism regulation of the germinal center response.生发中心反应的免疫代谢调节
Exp Mol Med. 2020 Mar;52(3):348-355. doi: 10.1038/s12276-020-0392-2. Epub 2020 Mar 4.
5
Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4 T Cell Metabolic Rewiring.慢性炎症部位的乳酸堆积通过诱导 CD4 T 细胞代谢重编程促进疾病发生。
Cell Metab. 2019 Dec 3;30(6):1055-1074.e8. doi: 10.1016/j.cmet.2019.10.004. Epub 2019 Nov 7.
6
Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modeling.分类抗体阴性 NMO 综合征：临床、影像和代谢组学建模。
Neurol Neuroimmunol Neuroinflamm. 2019 Oct 28;6(6):e626. doi: 10.1212/NXI.0000000000000626. Print 2019 Nov.
7
Regulation of metabolic supply and demand during B cell activation and subsequent differentiation.B 细胞活化及随后分化过程中代谢供需的调节。
Curr Opin Immunol. 2019 Apr;57:8-14. doi: 10.1016/j.coi.2018.10.003. Epub 2018 Oct 16.
8
Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis.门脉血液和胆汁代谢组学分析揭示原发性硬化性胆管炎的代谢特征。
Int J Mol Sci. 2018 Oct 16;19(10):3188. doi: 10.3390/ijms19103188.
9
IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis.IgG4 相关硬化性胆管炎与原发性硬化性胆管炎。
Gut Liver. 2019 May 15;13(3):300-307. doi: 10.5009/gnl18085.
10
Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis.血浆磁共振代谢组学可区分溃疡性结肠炎患者内镜高活动度与低活动度，并预测其进展。
J Crohns Colitis. 2018 Nov 15;12(11):1326-1337. doi: 10.1093/ecco-jcc/jjy101.