风湿性疾病中的脂质代谢谱
Lipid Metabolism Profiles in Rheumatic Diseases.
作者信息
Chen Weilin, Wang Qi, Zhou Bin, Zhang Lihua, Zhu Honglin
机构信息
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
出版信息
Front Pharmacol. 2021 Apr 9;12:643520. doi: 10.3389/fphar.2021.643520. eCollection 2021.
Abstract
Rheumatic diseases are a group of chronic autoimmune disorders that involve multiple organs or systems and have high mortality. The mechanisms of these diseases are still ill-defined, and targeted therapeutic strategies are still challenging for physicians. Recent research indicates that cell metabolism plays important roles in the pathogenesis of rheumatic diseases. In this review, we mainly focus on lipid metabolism profiles (dyslipidaemia, fatty acid metabolism) and mechanisms in rheumatic diseases and discuss potential clinical applications based on lipid metabolism profiles.
摘要
风湿性疾病是一组慢性自身免疫性疾病，累及多个器官或系统，死亡率高。这些疾病的发病机制仍不明确，针对这些疾病的治疗策略对医生来说仍然具有挑战性。最近的研究表明，细胞代谢在风湿性疾病的发病机制中起重要作用。在这篇综述中，我们主要关注风湿性疾病中的脂质代谢概况（血脂异常、脂肪酸代谢）及其机制，并基于脂质代谢概况讨论潜在的临床应用。
相似文献
1
Lipid Metabolism Profiles in Rheumatic Diseases.风湿性疾病中的脂质代谢谱
Front Pharmacol. 2021 Apr 9;12:643520. doi: 10.3389/fphar.2021.643520. eCollection 2021.
2
Blocking IL-17: A Promising Strategy in the Treatment of Systemic Rheumatic Diseases.阻断白介素-17：治疗全身性风湿性疾病的一种有前途的策略。
Int J Mol Sci. 2020 Sep 26;21(19):7100. doi: 10.3390/ijms21197100.
3
Statins and cardiovascular risk in rheumatic diseases.他汀类药物与风湿性疾病的心血管风险。
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):25-30. doi: 10.1177/039463201202500104.
4
The function of ncRNAs in rheumatic diseases.ncRNAs 在风湿性疾病中的作用。
Epigenomics. 2019 May;11(7):821-833. doi: 10.2217/epi-2018-0135. Epub 2019 Jun 7.
5
Role of inflammasomes in inflammatory autoimmune rheumatic diseases.炎性小体在炎症性自身免疫性风湿病中的作用。
Korean J Physiol Pharmacol. 2018 Jan;22(1):1-15. doi: 10.4196/kjpp.2018.22.1.1. Epub 2017 Dec 22.
6
Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians.系统性风湿病的心血管累及：治疗医师的综合观点。
Autoimmun Rev. 2018 Mar;17(3):201-214. doi: 10.1016/j.autrev.2017.12.001. Epub 2018 Jan 31.
7
[Autoimmune rheumatic diseases associated with HIV infection and its pathogenesis].[与HIV感染相关的自身免疫性风湿性疾病及其发病机制]
Nihon Rinsho. 1997 Jun;55(6):1486-91.
8
Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type.风湿性疾病中的单细胞测序：从细胞类型角度的新见解
Aging Dis. 2022 Dec 1;13(6):1633-1651. doi: 10.14336/AD.2022.0323.
9
Design and rationale of the ODYSSEY DM-DYSLIPIDEMIA trial: lipid-lowering efficacy and safety of alirocumab in individuals with type 2 diabetes and mixed dyslipidaemia at high cardiovascular risk.ODYSSEY DM-血脂异常试验的设计与原理：阿利西尤单抗在心血管高危2型糖尿病合并混合性血脂异常患者中的降脂疗效与安全性
Cardiovasc Diabetol. 2017 May 25;16(1):70. doi: 10.1186/s12933-017-0552-4.
10
Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications.用于风湿性疾病相关蛋白质的适配体：诊断与治疗应用的进展、挑战及前景
Biomedicines. 2020 Nov 22;8(11):527. doi: 10.3390/biomedicines8110527.
引用本文的文献
1
Association of the lipidome with type 1 diabetes and the mediated effect of metabolites: A Mendelian randomization study.脂质组与1型糖尿病的关联及代谢物的介导作用：一项孟德尔随机化研究
Medicine (Baltimore). 2025 Jun 13;104(24):e42755. doi: 10.1097/MD.0000000000042755.
2
Erythrocyte Membrane Fingerprints in the Veterinary Field: The Importance of Membrane Profiling and Its Application in Companion Animals.兽医领域中的红细胞膜指纹图谱：膜分析的重要性及其在伴侣动物中的应用
Biomolecules. 2025 May 14;15(5):718. doi: 10.3390/biom15050718.
3
Isorhamnetin: what is the evidence for its antitumor potential and beyond?异鼠李素：其抗肿瘤潜力及其他方面的证据有哪些？
Front Pharmacol. 2024 Apr 8;15:1309178. doi: 10.3389/fphar.2024.1309178. eCollection 2024.
4
Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study.血脂水平与系统性硬化症发病风险的关联：一项基于全国人口的研究。
Clin Epidemiol. 2023 Nov 29;15:1095-1107. doi: 10.2147/CLEP.S427881. eCollection 2023.
5
Ceramides in Autoimmune Rheumatic Diseases: Existing Evidence and Therapeutic Considerations for Diet as an Anticeramide Treatment.自身免疫性风湿病中的神经酰胺：饮食作为抗神经酰胺治疗的现有证据和治疗考虑因素。
Nutrients. 2023 Jan 2;15(1):229. doi: 10.3390/nu15010229.
6
Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study.日本胆石病发病的危险因素：基于人群的队列研究——静冈研究结果
PLoS One. 2022 Dec 30;17(12):e0274659. doi: 10.1371/journal.pone.0274659. eCollection 2022.
7
Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis.以中药活性成分靶向免疫代谢治疗类风湿关节炎
Chin Herb Med. 2021 Sep 20;13(4):451-460. doi: 10.1016/j.chmed.2021.09.005. eCollection 2021 Oct.
8
Incident Rheumatoid Arthritis Following Statin Use: From the View of a National Cohort Study in Korea.他汀类药物使用后发生的类风湿关节炎：来自韩国一项全国队列研究的视角
J Pers Med. 2022 Apr 1;12(4):559. doi: 10.3390/jpm12040559.
9
The foundations and development of lipidomics.脂质组学的基础与发展。
J Lipid Res. 2022 Feb;63(2):100164. doi: 10.1016/j.jlr.2021.100164. Epub 2021 Dec 22.
10
Plasma Metabolome Normalization in Rheumatoid Arthritis Following Initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy.甲氨蝶呤起始治疗后类风湿关节炎患者血浆代谢组的标准化及疗效代谢生物标志物的鉴定
Metabolites. 2021 Nov 30;11(12):824. doi: 10.3390/metabo11120824.
本文引用的文献
1
Change in skeletal muscle mass is associated with lipid profiles in female rheumatoid arthritis patients -TOMORROW study.骨骼肌质量变化与女性类风湿关节炎患者的脂质谱有关-TOMORROW 研究。
Clin Nutr. 2021 Jun;40(6):4500-4506. doi: 10.1016/j.clnu.2020.12.028. Epub 2020 Dec 25.
2
Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.脂肪酸感应G蛋白偶联受体（GPR84）信号传导可维护软骨稳态并预防骨关节炎。
Pharmacol Res. 2021 Feb;164:105406. doi: 10.1016/j.phrs.2020.105406. Epub 2020 Dec 24.
3
Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study.埃塞俄比亚亚的斯亚贝巴提库尔安贝萨专科医院类风湿关节炎患者血清脂质谱和高敏C反应蛋白的评估：一项横断面研究
Open Access Rheumatol. 2020 Sep 23;12:223-232. doi: 10.2147/OARRR.S264466. eCollection 2020.
4
Suppression of up-regulated LXRα by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism.水飞蓟宾通过抑制上调的 LXRα 改善实验性类风湿关节炎和异常脂质代谢。
Phytomedicine. 2021 Jan;80:153339. doi: 10.1016/j.phymed.2020.153339. Epub 2020 Sep 19.
5
Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients.系统性硬化症患者的脂肪酸和肉碱代谢失调。
Front Immunol. 2020 May 22;11:822. doi: 10.3389/fimmu.2020.00822. eCollection 2020.
6
Free Fatty Acids in Bone Pathophysiology of Rheumatic Diseases.游离脂肪酸在风湿性疾病骨病理生理学中的作用。
Front Immunol. 2019 Dec 3;10:2757. doi: 10.3389/fimmu.2019.02757. eCollection 2019.
7
High-Density Lipoprotein in Lupus: Disease Biomarkers and Potential Therapeutic Strategy.狼疮患者的高密度脂蛋白：疾病生物标志物和潜在治疗策略。
Arthritis Rheumatol. 2020 Jan;72(1):20-30. doi: 10.1002/art.41059. Epub 2019 Nov 26.
8
Research developments in metabolism 2018.2018年新陈代谢领域的研究进展
Metabolism. 2019 Feb;91:70-79. doi: 10.1016/j.metabol.2018.11.011. Epub 2018 Nov 29.
9
Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results.解析素 D1 在系统性红斑狼疮中的作用：初步研究结果。
J Immunol Res. 2018 Oct 21;2018:5264195. doi: 10.1155/2018/5264195. eCollection 2018.
10
Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies.基于临床表现和肌炎特异性自身抗体的特发性炎性肌病新分类系统的建立。
JAMA Neurol. 2018 Dec 1;75(12):1528-1537. doi: 10.1001/jamaneurol.2018.2598.
Zotero 插件