Department of Neuroscience-Neurology Section, University of Siena, Siena, Italy.
Neurobiol Aging. 2011 Mar;32(3):552.e7-13. doi: 10.1016/j.neurobiolaging.2010.02.010. Epub 2010 Apr 9.
Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
对氧磷酶（PON）基因多态性与散发型肌萎缩侧索硬化症（ALS）的易感性有关。我们研究了先前与单核苷酸多态性 rs854560、rs662 和 rs6954345 相关的作用，在来自意大利的 350 名 ALS 患者和 376 名匹配对照中进行了研究。在基因型和单倍型水平均未观察到显著相关性。我们的数据表明，对氧磷酶多态性在意大利人群中不参与 ALS 的发病机制。
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