Department of Neurology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Neurobiol Aging. 2012 Dec;33(12):2949.e1-3. doi: 10.1016/j.neurobiolaging.2012.06.024. Epub 2012 Aug 9.
Single nucleotide polymorphisms (SNPs) of the paraoxonase gene family (ordered PON1, PON2, and PON3) have been associated with the risk of developing sporadic amyotrophic lateral sclerosis (SALS) in Caucasian populations. However, this association has yet to be confirmed in Chinese SALS patients. Nine SNPs across the PON gene cluster (i.e., rs662, rs705381, rs705382, rs854548, rs854560, rs7493, rs11981433, rs757158, and rs10487132) were analyzed in a large cohort consisting of 373 SALS patients and 248 controls from Southwest China. The data from the present study suggest that these SNPs of the PON gene cluster do not contribute to the risk for developing SALS in a Chinese population.
单核苷酸多态性（SNPs）的对氧磷酶基因家族（有序 PON1、PON2 和 PON3）已与散发性肌萎缩侧索硬化症（SALS）的风险相关联在白种人群体中。然而，这种关联尚未在中国 SALS 患者中得到证实。在中国西南地区的一个由 373 名 SALS 患者和 248 名对照组成的大样本中，分析了 PON 基因簇的 9 个 SNPs（即 rs662、rs705381、rs705382、rs854548、rs854560、rs7493、rs11981433、rs757158 和 rs10487132）。本研究的数据表明，PON 基因簇的这些 SNPs 不会导致中国人患 SALS 的风险增加。
