Cai Tommaso, Mazzoli S, Addonisio P, Boddi V, Geppetti P, Bartoletti R
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy.
Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):39-45. doi: 10.1358/mf.2010.32.1.1423885.
The purpose of this study was to compare the efficacy of a 14-day course of prulifloxacin 600 mg with standard antibiotic therapy for the treatment of chronic prostatitis due to Chlamydia trachomatis (Ct) infection. All patients with clinical and instrumental diagnosis of bacterial chronic prostatitis (CP) due to Ct infection were enrolled. After randomization, all patients were administered oral prulifloxacin 600 mg once daily for 14 days or doxycycline 100 mg orally twice daily for 21 days. At enrollment and 30 days after beginning treatment, all patients underwent microbiological cultures for uropathogens bacteria and yeasts, DNA extraction and mucosal IgA evaluation for Ct diagnosis, seminal plasma IL-8 evaluation and serum IgA and IgG anti-Ct analysis. The National Institutes of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) was given to each patient. A total of 109 patients received prulifloxacin and 102 received standard therapy. Prulifloxacin had clinical efficacy rates equivalent to standard therapy (82.5% vs. 79.9%) (P = 0.08) and showed superior microbiological efficacy rates compared to standard therapy, in terms of decreasing mucosal IgA (P < 0.001) and IL-8 levels (P < 0.001). Prulifloxacin was also equivalent to standard therapy for clinical success, as demonstrated by a decrease in the number of patients affected by CP due to Ct infection.
本研究的目的是比较600毫克普卢利沙星14天疗程与标准抗生素疗法治疗沙眼衣原体（Ct）感染所致慢性前列腺炎的疗效。纳入所有经临床和仪器诊断为Ct感染所致细菌性慢性前列腺炎（CP）的患者。随机分组后，所有患者接受口服普卢利沙星600毫克，每日一次，共14天，或口服强力霉素100毫克，每日两次，共21天。在入组时和开始治疗后30天，所有患者均接受尿路致病菌和酵母菌的微生物培养、DNA提取以及用于Ct诊断的黏膜IgA评估、精浆IL-8评估以及血清IgA和IgG抗Ct分析。对每位患者进行美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）评估。共有109例患者接受普卢利沙星治疗，102例接受标准治疗。普卢利沙星的临床有效率与标准疗法相当（82.5%对79.9%）（P = 0.08），并且在降低黏膜IgA（P < 0.001）和IL-8水平（P < 0.001）方面，其微生物学有效率优于标准疗法。在因Ct感染所致CP患者数量减少方面，普卢利沙星在临床疗效上也与标准疗法相当。
