Pulito Claudio, Mori Federica, Sacconi Andrea, Casadei Luca, Ferraiuolo Maria, Valerio Maria Cristina, Santoro Raffaela, Goeman Frauke, Maidecchi Anna, Mattoli Luisa, Manetti Cesare, Di Agostino Silvia, Muti Paola, Blandino Giovanni, Strano Sabrina
Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
Oncotarget. 2015 Jul 20;6(20):18134-50. doi: 10.18632/oncotarget.4017.
Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.
恶性胸膜间皮瘤是一种起源于胸膜间皮内衬的难治性肿瘤。在此我们证明，水飞蓟提取物在体外和体内对间皮瘤细胞系均具有广泛的抗肿瘤作用。我们发现，水飞蓟处理对间皮瘤细胞系的细胞生长、迁移和肿瘤植入有强烈影响。令人惊讶的是，用飞蓟叶提取物进行饮食喂养可使间皮瘤异种移植肿瘤的生长减少，其效果与培美曲塞（一种常用于治疗间皮瘤的药物）相似。总的来说，我们的研究结果表明，水飞蓟叶提取物在间皮瘤治疗方面具有治疗潜力。
