Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Environ Sci Technol. 2010 Apr 15;44(8):2870-5. doi: 10.1021/es9021427.
Human exposure to individual polychlorinated biphenyl (PCB) congeners and dichloro-diphenyldichloroethylene (p,p'-DDE) through food (duplicate diets) and indoor dust ingestion was assessed for 19 Belgian students. The serum concentrations of the persistent PCB congeners in serum (PCB 118, 138, 153, 170, and 180) have been correlated with the individual intake through food and dust. Dietary intakes of SigmaPCBs ranged between 40 and 204 ng/day (median 133). PCB exposure through dust ingestion ranged between 0.1 and 0.8 ng/day (median 0.3) or 0.3 and 1.7 ng/day (median 0.8), assuming average dust ingestion (20 mg/day) and high dust ingestion rates (50 mg/day), respectively. Dietary intake of p,p'-DDE was comparable to that of PCBs with a range from 21 to 214 ng/day (median 92). The exposure to p,p'-DDE via dust ingestion ranged between 0.02 and 0.43 ng/day (median 0.17) or 0.05 and 1.09 ng/day (median 0.43), assuming average and high dust ingestion rates, respectively. Concentrations measured in blood serum were 28-153 ng/g lipid weight (lw) (median 74) and 32-264 ng/g lw (median 45) for SigmaPCBs and p,p'-DDE, respectively. Serum concentrations in the studied population are slightly lower compared to other European populations. In spite of the uncertainty associated with the dust ingestion rates, food was the predominant exposure pathway for each PCB congener and for p,p'-DDE in the studied population. Food intake contributed more than 99% of the combined PCB intake from food and dust. No significant positive correlations (p > 0.05) were observed between the serum concentrations of PCBs and p,p'-DDE and the total intake through food and dust for each participant. Instead, it is hypothesized that past and episodic higher current intakes are more important determinants of body burden than continuous background exposures at low levels.
对 19 名比利时学生进行了个体多氯联苯 (PCB) 同系物和二氯二苯二氯乙烯 (p,p'-DDE) 的食物（重复饮食）和室内灰尘摄入暴露评估。血清中持久性 PCB 同系物（PCB118、138、153、170 和 180）的浓度与通过食物和灰尘摄入的个体摄入量相关。SigmaPCBs 的膳食摄入量在 40 到 204ng/天之间（中位数为 133ng/天）。通过灰尘摄入摄入 PCB 的暴露量在 0.1 到 0.8ng/天之间（中位数为 0.3ng/天）或 0.3 到 1.7ng/天之间（中位数为 0.8ng/天），分别假设平均灰尘摄入量（20mg/天）和高灰尘摄入量（50mg/天）。p,p'-DDE 的膳食摄入量与 PCB 相当，范围在 21 到 214ng/天之间（中位数为 92ng/天）。通过灰尘摄入摄入 p,p'-DDE 的暴露量在 0.02 到 0.43ng/天之间（中位数为 0.17ng/天）或 0.05 到 1.09ng/天之间（中位数为 0.43ng/天），分别假设平均和高灰尘摄入量。血清中测量的 SigmaPCBs 和 p,p'-DDE 的浓度分别为 28-153ng/g 脂质重量（lw）（中位数为 74ng/g lw）和 32-264ng/g lw（中位数为 45ng/g lw）。与其他欧洲人群相比，研究人群中的血液浓度略低。尽管灰尘摄入率存在不确定性，但食物是研究人群中每种 PCB 同系物和 p,p'-DDE 的主要暴露途径。食物摄入量占食物和灰尘摄入总和的 99%以上。对于每个参与者，血清中 PCB 和 p,p'-DDE 浓度与通过食物和灰尘的总摄入量之间没有观察到显著的正相关（p>0.05）。相反，假设过去和偶发性更高的当前摄入量比低水平的连续背景暴露更能决定体内负担。
