Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
J Eur Acad Dermatol Venereol. 2010 Dec;24(12):1476-80. doi: 10.1111/j.1468-3083.2010.03675.x.
Dermatological disorders are quite common in human immunodeficiency virus (HIV)-infected patients. However, cutaneous findings in Korean HIV-infected patients have not been properly investigated.
To investigate the spectrum of dermatological disorders in Korean HIV-infected individuals according to a CD4 lymphocyte count.
A retrospective clinical study was carried out from June 2002 to January 2008. We comprehensively collected information regarding HIV-associated skin problems, laboratory data and the history of highly active antiretroviral therapy (HAART).
Ninety-nine HIV-seropositive patients (mean age: 39.6 ± 11.3 years, males: 94.9%) were included in this study. Of them, 55 patients (55.6%) presented with at least one skin problem. The four most common dermatological disorders were eosinophilic pustular folliculitis (18.6%), symptomatic syphilis (comprising of primary and secondary syphilis) (17.1%), seborrhoeic dermatitis (17.1%) and condyloma acuminatum (12.8%). The group with a CD4 lymphocyte count < 200 · 10⁶ cells ⁄ L showed a significantly higher prevalence of Kaposi sarcoma compared with the group with a CD4 lymphocyte count > 200 · 10⁶ cells ⁄ L (P = 0.014). Condyloma was more prevalent in the group with a CD4 count > 200 · 10⁶ cells ⁄ L (P = 0.022). The patients treated with HAART had a lower prevalence of neurosyphilis compared with the non-treated group (P = 0.018).
Diverse dermatological conditions were demonstrated in Korean HIV-infected patients. Kaposi sarcoma was associated with a low CD4 lymphocyte count, but condyloma was associated with a high CD4 lymphocyte count. The prevalence of syphilis in our study was higher than that of Western countries. HAART seemed to be associated with the low prevalence of neurosyphilis.
皮肤科疾病在人类免疫缺陷病毒（HIV）感染者中较为常见。然而，韩国 HIV 感染者的皮肤表现尚未得到充分研究。
根据 CD4 淋巴细胞计数调查韩国 HIV 感染者的皮肤科疾病谱。
进行了一项回顾性临床研究，时间为 2002 年 6 月至 2008 年 1 月。我们全面收集了有关 HIV 相关皮肤问题、实验室数据和高效抗逆转录病毒治疗（HAART）史的信息。
本研究纳入 99 例 HIV 血清阳性患者（平均年龄：39.6 ± 11.3 岁，男性：94.9%）。其中，55 例（55.6%）患者至少存在一种皮肤问题。最常见的四种皮肤科疾病为嗜酸性脓疱性毛囊炎（18.6%）、症状性梅毒（包括一期和二期梅毒）（17.1%）、脂溢性皮炎（17.1%）和尖锐湿疣（12.8%）。CD4 淋巴细胞计数 < 200·10⁶个细胞/L 的患者中卡波西肉瘤的患病率明显高于 CD4 淋巴细胞计数 > 200·10⁶个细胞/L 的患者（P = 0.014）。CD4 计数 > 200·10⁶个细胞/L 的患者中尖锐湿疣更为常见（P = 0.022）。与未接受 HAART 治疗的患者相比，接受 HAART 治疗的患者神经梅毒的患病率较低（P = 0.018）。
韩国 HIV 感染者存在多种皮肤科疾病。卡波西肉瘤与低 CD4 淋巴细胞计数相关，而尖锐湿疣与高 CD4 淋巴细胞计数相关。本研究中梅毒的患病率高于西方国家。HAART 似乎与神经梅毒的低患病率相关。
