Dwiyana Reiva Farah, Rowawi Rasmia, Lestari Mery, Alisjahbana Bachti, van der Ven A J A M, Djajakusumah Tony S
Department of Dermato-Venereology, Padjadjaran University/Hasan Sadikin Hospital. Jl. Pasirkaliki no. 190, Bandung 40151, Indonesia.
Acta Med Indones. 2009 Jul;41 Suppl 1:18-22.
to describe the spectrum of HIV-related skin disorders as well as their prevalence and relation to CD4-cell counts among HIV-seropositive patients from West Java, Indonesia.
all HIV-positive patients presenting in 2008 at the HIV-clinic, Hasan Sadikin Hospital, were included in a cross-sectional study. Patients who had a skin complaint were examined by a dermatologist. Skin diseases were classified based on ICD 10.
among 843 patients, 121 (14.4%) had a skin complaint, consisting of skin manifestations (73.3%), drug eruptions (30.5%), and sexually transmitted infections (15.7%), some of them had more than one diseases. The most common skin manifestations were drug eruptions, pruritic papular eruptions, seborrhoeic dermatitis, herpes zoster, dermatophytosis, and bacterial skin infections. Among patients who started nevirapine, 6.4% (95%CI: 3.9% - 8.9%) developed any kind of drug eruption, and 1.4% (95%CI 0.2%-2.6%) developed a severe drug eruption. No cases of Kaposi sarcoma, penicilliosis, eosinophilic folliculitis were seen, however one case of histoplasmosis was diagnosed.
this is the first report describing the prevalence and characteristic of skin manifestation in HIV-positive in Indonesia. Indonesian physicians should be alert about HIV when patient presents with certain skin manifestations. The rate of severe drug eruptions following treatment with nevirapine is a cause of concern that needs further study.
描述印度尼西亚西爪哇地区HIV血清阳性患者中与HIV相关的皮肤疾病谱、患病率及其与CD4细胞计数的关系。
2008年在哈桑·萨迪金医院HIV门诊就诊的所有HIV阳性患者纳入一项横断面研究。有皮肤问题的患者由皮肤科医生进行检查。皮肤疾病根据国际疾病分类第10版进行分类。
843例患者中，121例（14.4%）有皮肤问题，包括皮肤表现（73.3%）、药疹（30.5%）和性传播感染（15.7%），其中一些患者患有一种以上疾病。最常见的皮肤表现是药疹、瘙痒性丘疹性皮疹、脂溢性皮炎、带状疱疹、皮肤癣菌病和细菌性皮肤感染。在开始使用奈韦拉平的患者中，6.4%（95%可信区间：3.9% - 8.9%）出现任何类型的药疹，1.4%（95%可信区间0.2% - 2.6%）出现严重药疹。未发现卡波西肉瘤、青霉病、嗜酸性毛囊炎病例，但诊断出1例组织胞浆菌病。
这是第一份描述印度尼西亚HIV阳性患者皮肤表现患病率和特征的报告。当患者出现某些皮肤表现时，印度尼西亚医生应警惕HIV。奈韦拉平治疗后严重药疹的发生率令人担忧，需要进一步研究。
