通过 In(OTf)3 催化的芳基碘化反应实现天然产物的温和衍生化。
Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.
机构信息
Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77842-3012, USA.
出版信息
Org Lett. 2010 May 7;12(9):2104-7. doi: 10.1021/ol100587j.
Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)(3) at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.
采用 N-碘代琥珀酰亚胺（N-iodosuccinimide）在三氟化铟（In(OTf)(3)）催化下，室温下对含芳环的天然产物进行碘化反应，报道了一种通用且温和的天然产物衍生化方法，适用于小规模反应。该方法促进了芳环部分的天然产物衍生化，用于 SAR 研究、天然产物的同二聚和异二聚以及与生物素等报告分子的连接，通过后续的金属介导偶联反应。
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