Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc. 2016 Oct 5;138(39):12692-12714. doi: 10.1021/jacs.6b08856. Epub 2016 Sep 26.
This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history. Studies from our laboratory are discussed along with recent developments emanating from others in this burgeoning area. The practicality and chemoselectivity of radical reactions enable rapid access to molecules of relevance to drug discovery, agrochemistry, material science, and other disciplines. Thus, these reactive intermediates possess inherent translational potential, as they can be widely used to expedite scientific endeavors for the betterment of humankind.
本文视角阐述了自由基化学的定义特征，从其丰富而悠久的历史开始。讨论了我们实验室的研究工作，并结合该新兴领域中其他实验室的最新进展进行了阐述。自由基反应的实用性和化学选择性使得快速获得与药物发现、农艺化学、材料科学和其他学科相关的分子成为可能。因此，这些反应中间体具有内在的转化潜力，因为它们可以广泛用于加速科学研究，造福人类。
