Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy.
Curr Drug Targets. 2010 Jul;11(7):882-7. doi: 10.2174/138945010791320881.
Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the pathogenesis/progression of atherosclerosis and its serious consequences such as acute myocardial infarction (AMI), stroke, aortic aneurysms, and intimal hyperplasia. LT biosynthetic enzymes are expressed within atherosclerotic lesion, leading to production of cysteinyl-leukotrienes (Cys-LTs) and LTB4 that exert potent pro-inflammatory action through interaction with CysLT and BLT receptor subtypes expressed on inflammatory and structural cells within the vascular wall. Genetic variants in the genes of the 5-LO pathway have been associated with the risk of developing AMI and stroke. As a result, anti-LT have recently received renewed interest for the treatment of atherosclerosis and its ischemic complications. The aim of this short review is to summarize our current understanding of the role of LTs and their receptors in the genesis and progression of atherosclerosis and review the recent developments on the use of antagonists.
实验和遗传研究的证据表明，白三烯（LT）信号级联与动脉粥样硬化的发病机制/进展及其严重后果（如急性心肌梗死（AMI）、中风、主动脉瘤和内膜增生）之间存在潜在联系。LT 生物合成酶在动脉粥样硬化病变中表达，导致半胱氨酰白三烯（Cys-LTs）和 LTB4 的产生，通过与血管壁内炎症和结构细胞表达的 CysLT 和 BLT 受体亚型相互作用，发挥强烈的促炎作用。5-LO 途径基因中的遗传变异与发生 AMI 和中风的风险相关。因此，抗 LT 最近重新引起了人们对治疗动脉粥样硬化及其缺血性并发症的兴趣。这篇短文的目的是总结我们对白三烯及其受体在动脉粥样硬化发生和进展中的作用的理解，并综述拮抗剂使用的最新进展。
