用于癌症成像的可激活分子探针。

Activatable molecular probes for cancer imaging.

机构信息

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Dr, Suite 1C14, Bethesda, MD 20892-2281, USA.

出版信息

Curr Top Med Chem. 2010;10(11):1135-44. doi: 10.2174/156802610791384270.

DOI:10.2174/156802610791384270

PMID:20388112

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3629980/

Abstract

The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.

摘要

高度敏感和特异的用于癌症成像的分子探针的开发仍然是一个艰巨的挑战。最近，成像科学和生物共轭化学界面的交叉学科研究产生了新型的可激活成像探针，可提供具有超低背景信号的高分辨率成像。可激活的成像探针旨在实时响应特定的生物分子识别或环境变化，放大输出成像信号。本文介绍并强调了各种可激活成像探针在癌症成像中的独特设计策略和应用。