Anari S, Carrie S
Department of Otolaryngology/Head and Neck Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
J Laryngol Otol. 2010 Jul;124(7):705-15. doi: 10.1017/S0022215110000599. Epub 2010 Apr 14.
Sinonasal inverted papilloma is a benign condition with the potential for recurrence and malignant change. Over the past few decades, numerous studies and reviews have addressed different aspects of this condition.
To amalgamate the current literature on inverted papilloma, in order to review the evidence and consider the gaps in current knowledge.
Retrospective, narrative review.
The reported incidence of inverted papilloma varies between centres and is affected by selection bias. The exact aetiology of inverted papilloma is not fully understood. Currently, there is no reliable histological or biological marker to predict the probability of recurrence or malignant transformation. There is no universally accepted staging system available for sinonasal inverted papilloma. Complete surgical removal of the tumour is the mainstay of treatment, but the method of choice depends on the extent of the disease, the skill of the surgeon and the technology available.
In order to compare different studies and to enable meta-analysis of the literature, there should be a universally accepted staging and classification system for sinonasal inverted papilloma. Further research on the aetiology of sinonasal inverted papilloma, and on biological markers for its recurrence and malignant transformation, is required. To enable meaningful future research, we would encourage multicentre participation with a consensus on management.
鼻窦内翻性乳头状瘤是一种良性疾病，但有复发和恶变的可能。在过去几十年中，众多研究和综述探讨了该疾病的不同方面。
整合当前关于内翻性乳头状瘤的文献，以回顾证据并考量现有知识的空白。
回顾性叙述性综述。
报道的内翻性乳头状瘤发病率因研究中心而异，并受选择偏倚影响。内翻性乳头状瘤的确切病因尚未完全明确。目前，尚无可靠的组织学或生物学标志物来预测复发或恶变的可能性。鼻窦内翻性乳头状瘤尚无普遍接受的分期系统。肿瘤的完整手术切除是主要治疗手段，但选择的方法取决于疾病范围、外科医生的技术水平和可用技术。
为了比较不同研究并进行文献的荟萃分析，鼻窦内翻性乳头状瘤应有一个普遍接受的分期和分类系统。需要进一步研究鼻窦内翻性乳头状瘤的病因及其复发和恶变的生物学标志物。为了开展有意义的未来研究，我们鼓励多中心参与并就管理达成共识。
