Li Qinghui, Zhu Jiang
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Jun;28(11):797-800.
To investigate the clinical characteristics, treatment and the effectiveness of sinonasal inverting papilloma with recurrence and malignant transformation.
Retrospective comparative analysis of sinonasal inverting papilloma with recurrence and malignant transformation treated from Jan. 2008 to Oct. 2012 in our hospital.
All the 24 patients with recurrence had the history of sinonasal surgery. Among them, 17 patients recurred once,6 recurred twice and 1 recurred three times. The recurrence time was from 1 month to 14 years after operation. Four patients relapsed within half year after 5 months to 4 years follow-up and the recurrence ratio was 16.7% (4/24). All the 4 patients with recurrence had an operation once again and one of them was given chemoradiotherapy after surgery whose pathological results showed canceration. There was no recurrence among the all of 24 patients followed up until now. Among 5 patients with malignant transformation, 3 patients of them were given radiochemotherapy after surgery. Except 1 patient died of extensive recurrence, 1 received other operation after relapsed twice and 1 lost follow up,all the others were alive without recurrence during 10 months to 4 years.
The surgical treatment with completely and positively is the firse choice and an effective management for sinonasal inverting papilloma. To the patients with recurrence on many times and malignant tumors, post-operative radiation or chemotherapy should be considered when needed.
探讨复发性及恶变鼻内翻性乳头状瘤的临床特点、治疗方法及疗效。
回顾性分析2008年1月至2012年10月我院收治的复发性及恶变鼻内翻性乳头状瘤患者的临床资料。
24例复发性患者均有鼻鼻窦手术史。其中，17例复发1次，6例复发2次，1例复发3次。复发时间为术后1个月至14年。4例患者在随访5个月至4年后半年内复发，复发率为16.7%（4/24）。4例复发患者均再次手术，其中1例术后病理提示癌变，术后给予放化疗。目前24例患者均无复发。5例恶变患者中，3例术后给予放化疗。除1例因广泛复发死亡、1例复发2次后再次手术、1例失访外，其余患者在10个月至4年内均存活且无复发。
彻底、积极的手术治疗是鼻内翻性乳头状瘤的首选及有效治疗方法。对于多次复发及恶变肿瘤患者，必要时应考虑术后放疗或化疗。
