Chi Ying, Wang Yin-hua, Yang Liu
Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China.
Zhonghua Yan Ke Za Zhi. 2010 Feb;46(2):134-9.
To determine if there are retinal abnormalities in Alzheimer's disease and if retinal changes are one of the causes of the visual symptom, and if the changes of retina thickness correlated with the severity of dementia.
Case-control study. Twelve patients of Alzheimer's disease and seventeen normal controls were included. General eye examinations, mini-mental state examination (MMSE) score and OCT were performed on each patient. Independent-samples t test was used to compare the results obtained from these two groups.
The retinal nerve fiber layer (RNFL thickness) overall:Alzheimer's (93.18 +/- 11.36) microm, control (99.44 +/- 8.88) microm, macula thickness min: Alzheimer's (204.00 +/- 52.06) microm, control (211.36 +/- 49.09) microm; inner 1 mm: Alzheimer's (232.50 +/- 23.37) microm, control (242.79 +/- 40.36) microm; between 1-3 mm: Alzheimer's (289.42 +/- 21.37) microm, control (298.43 +/- 23.30) microm; between 3 - 6 mm: Alzheimer's (256.67 +/- 20.04) microm, control (262.86 +/- 20.19) microm was thinner in the patients with Alzheimer's disease. Macula volume inner 1 mm: Alzheimer's (0.183 +/- 0.018) m(3), control (0.188 +/- 0.031) m(3): between 1 - 3 mm: Alzheimer's (1.819 +/- 0.134) m(3), control (1.875 +/- 0.147) m(3); between 3 - 6 mm Alzheimer's (5.443 +/- 0.424) m(3), control (5.571 +/- 0.428) m(3) in the Alzheimer's diseases patients was smaller than that of the controls. There was significant difference (t = -2.519, P < 0.05) in RNFL thickness of the superior quadrant between the two groups Alzheimer's disease (115.09 +/- 14.05) microm, control (129.23 +/- 10.69) microm.
There is retinal nerve fiber loss in patients with Alzheimer's disease, which may be responsible for the visual symptoms. The retinal nerve fiber loss is obviously in the superior quadrant, and it is correlated positively to the severity of dementia.
确定阿尔茨海默病患者是否存在视网膜异常，视网膜变化是否为视觉症状的原因之一，以及视网膜厚度变化是否与痴呆严重程度相关。
病例对照研究。纳入12例阿尔茨海默病患者和17名正常对照者。对每位患者进行常规眼科检查、简易精神状态检查表（MMSE）评分及光学相干断层扫描（OCT）。采用独立样本t检验比较两组结果。
视网膜神经纤维层（RNFL厚度）总体情况：阿尔茨海默病组（93.18±11.36）微米，对照组（99.44±8.88）微米；黄斑厚度最小值：阿尔茨海默病组（204.00±52.06）微米，对照组（211.36±49.09）微米；内侧1毫米处：阿尔茨海默病组（232.50±23.37）微米，对照组（242.79±40.36）微米；1 - 3毫米之间：阿尔茨海默病组（289.42±21.37）微米，对照组（298.43±23.30）微米；3 - 6毫米之间：阿尔茨海默病组（256.67±20.04）微米，对照组（262.86±20.19）微米，阿尔茨海默病患者的相应厚度更薄。内侧1毫米处黄斑体积：阿尔茨海默病组（0.183±0.018）立方米，对照组（0.188±0.031）立方米；1 - 3毫米之间：阿尔茨海默病组（1.819±0.134）立方米，对照组（1.875±0.147）立方米；3 - 6毫米之间：阿尔茨海默病组（5.443±0.424）立方米，对照组（5.571±0.428）立方米，阿尔茨海默病患者的黄斑体积小于对照组。两组之间上象限RNFL厚度存在显著差异（t = -2.519，P < 0.05），阿尔茨海默病组（115.09±14.05）微米，对照组（129.23±10.69）微米。
阿尔茨海默病患者存在视网膜神经纤维丢失，这可能是视觉症状的原因。视网膜神经纤维丢失在上象限明显，且与痴呆严重程度呈正相关。
