Cogliandolo A, Gulino F M, Pustorino S, Migliorato D, Bottari M, Saitta F P, Micali B
Cattedra di Chirurgia Generale e di Pronto Soccorso, Università degli Studi di Messina.
Minerva Chir. 1992 Jan;47(1-2):11-7.
Thirty-two patients with symptomatic gastroesophageal reflux disease were investigated by esophagogastroduodenoscopy, 24 h pH monitoring, esophageal manometry and measurement of gastric emptying of solids, in order to elucidate the relative importance of lower esophageal sphincter tone, amount of acid reflux and gastric emptying on the degree of esophagitis. The mechanical competency of lower esophageal sphincter was significantly deranged in patients with moderate/severe esophagitis than in patients with mild esophagitis. The gastric emptying time was significantly delayed in patients with moderate/severe esophagitis than in patients with mild esophagitis. No relationship was observed between amount of acid reflux, lower esophageal sphincter function and gastric emptying time. Our results suggest that resting pressure of lower esophageal sphincter and the gastric motor function play a major role in severity of reflux esophagitis.
对32例有症状的胃食管反流病患者进行了食管胃十二指肠镜检查、24小时pH监测、食管测压和固体胃排空测量，以阐明食管下括约肌张力、酸反流量和胃排空对食管炎程度的相对重要性。与轻度食管炎患者相比，中重度食管炎患者食管下括约肌的机械功能明显紊乱。与轻度食管炎患者相比，中重度食管炎患者的胃排空时间明显延迟。未观察到酸反流量、食管下括约肌功能和胃排空时间之间的关系。我们的结果表明，食管下括约肌的静息压力和胃运动功能在反流性食管炎的严重程度中起主要作用。
