He Kang, Du Jiang
Guiyang College of Traditional Chinese Medicine, Guiyang, China.
J Asian Nat Prod Res. 2010 Mar;12(3):233-8. doi: 10.1080/10286021003610136.
Two new steroidal alkaloids, 20alpha-dimethylamino-2alpha-hydroxyl-3beta-tigloylamino-5alpha-pregnane (1) and Delta(16)-20alpha-dimethylamino-3beta,4alpha-diol-5alpha-pregnane (2), along with five known alkaloids, sarcovagine D (3), pachysamine G (4), pachysamine H (5), pachysamine A (6), and terminaline (20S)-20-(N,N-dimethylamino)-5alpha-pregn-3beta,4alpha-diol (7), were isolated from the roots of Sarcococca ruscifolia. Their structures were elucidated on the basis of NMR and MS data, and the relative stereochemistry of 1 was finally determined by X-ray crystallographic analysis.
从皱叶百两金的根部分离得到两种新的甾体生物碱，20α-二甲基氨基-2α-羟基-3β-惕各酰氨基-5α-孕甾烷（1）和Δ（16）-20α-二甲基氨基-3β，4α-二醇-5α-孕甾烷（2），以及五种已知生物碱，假虎刺胺D（3）、粗榧胺G（4）、粗榧胺H（5）、粗榧胺A（6）和（20S）-20-（N，N-二甲基氨基）-5α-孕甾-3β，4α-二醇（7）。基于核磁共振和质谱数据阐明了它们的结构，1的相对立体化学最终通过X射线晶体学分析确定。
