钩果草中三个新的细胞毒性甾体生物碱。

Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana.

机构信息

The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China.

The Ethnical Medicine Research Institute of Qian Dong Nan Miao and Dong Autonomous Prefecture, Kaili 556000, Guizhou, China.

出版信息

Molecules. 2018 May 15;23(5):1181. doi: 10.3390/molecules23051181.

DOI:10.3390/molecules23051181

PMID:29762510

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6099570/

Abstract

Three new steroidal alkaloids with an unusual 3 tigloylamide group, named sarchookloides A⁻C (⁻), were isolated along with four known compounds (⁻) from the roots of . Their structures and relative configuration were elucidated on the basis of spectroscopic methods including MS, UV, IR, 1D, and 2D NMR data. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines: Hela, A549, MCF-7, SW480, and CEM in vitro. All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC values of 1.05⁻31.83 μM.

摘要

从中分离得到三个具有不寻常 3- tigloylamide 基团的新甾体生物碱，命名为 sarchookloides A⁻C (⁻)，以及四个已知化合物 (⁻)。基于包括 MS、UV、IR、1D 和 2D NMR 数据在内的光谱方法阐明了它们的结构和相对构型。对分离得到的化合物进行了体外细胞毒性评价，选择了五种人癌细胞系：Hela、A549、MCF-7、SW480 和 CEM。所有三种酰胺取代的甾体生物碱都表现出显著的细胞毒性，IC 值为 1.05⁻31.83 μM。