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威尔斯综合征——一段历程

Wells Syndrome - An Odyssey.

作者信息

Heinig Birgit, Vojvocic Aleksandra, Lotti Torello, Tirant Michael, Wollina Uwe

机构信息

Center of Physical and Rehabilitative Medicine, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.

Military Medical Academy of Belgrade, Belgrade, Serbia.

出版信息

Open Access Maced J Med Sci. 2019 Jun 30;7(18):3002-3005. doi: 10.3889/oamjms.2019.572. eCollection 2019 Sep 30.

DOI:10.3889/oamjms.2019.572
PMID:31850109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6910816/
Abstract

BACKGROUND

Wells syndrome is a rare idiopathic dermatosis of the eosinophilic spectrum. Diagnostic criteria include cutaneous eruptions of variable morphology with eosinophilic infiltrates, peripheral blood eosinophilia, a relapsing, remitting course, and exclusion of systemic disease. Diagnosis is often delayed.

CASE PRESENTATION

We present a 28-year older man with recently developed pruritic and sometimes painful erythema. His medical history was positive for coughing in the evening that started in November 2012. Later, a pansinusitis developed. Early diagnosis improves the outcome.

CONCLUSION

Standardized treatment has yet to be developed. In our case, systemic corticosteroids were of limited value only.

摘要

背景

韦尔斯综合征是一种罕见的嗜酸性粒细胞谱系特发性皮肤病。诊断标准包括形态多样的皮肤疹伴嗜酸性粒细胞浸润、外周血嗜酸性粒细胞增多、病情复发缓解过程以及排除全身性疾病。诊断往往延迟。

病例介绍

我们报告一名28岁男性,近期出现瘙痒且有时疼痛的红斑。他的病史显示2012年11月开始出现夜间咳嗽,随后发展为全鼻窦炎。早期诊断可改善预后。

结论

尚未制定标准化治疗方案。在我们的病例中,全身用皮质类固醇仅具有有限价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d124/6910816/2f4864f035e1/OAMJMS-7-3002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d124/6910816/10f28d1eea97/OAMJMS-7-3002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d124/6910816/2f4864f035e1/OAMJMS-7-3002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d124/6910816/10f28d1eea97/OAMJMS-7-3002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d124/6910816/2f4864f035e1/OAMJMS-7-3002-g002.jpg

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本文引用的文献

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Therapeutic strategies for eosinophilic dermatoses.嗜酸性粒细胞性皮炎的治疗策略。
Curr Opin Pharmacol. 2019 Jun;46:29-33. doi: 10.1016/j.coph.2019.01.002. Epub 2019 Feb 10.
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Wells' Syndrome Induced by Ustekinumab.优特克单抗诱发的威尔斯综合征。
Isr Med Assoc J. 2019 Jan;21(1):65.
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Wells syndrome in a patient receiving adalimumab biosimilar: A case report and review of literature.接受阿达木单抗生物类似药治疗的患者发生威尔斯综合征:一例病例报告及文献复习
酷似感染性蜂窝织炎的临床实体:嗜酸性粒细胞性蜂窝织炎(韦尔斯综合征)。
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Wells syndrome: a case of successful treatment with omalizumab.
Int J Dermatol. 2018 Aug;57(8):994-995. doi: 10.1111/ijd.14006. Epub 2018 Apr 29.
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Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.嗜酸性粒细胞性蜂窝织炎(韦尔斯综合征)的治疗——一项系统评价
J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1465-79. doi: 10.1111/jdv.13706. Epub 2016 Jun 29.
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Eosinophilic Skin Diseases: A Comprehensive Review.嗜酸性皮肤病:全面综述
Clin Rev Allergy Immunol. 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8.
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Life of lesions in eosinophilic cellulitis (Wells' syndrome)-a condition that may be missed at first sight.嗜酸性粒细胞性蜂窝织炎(韦尔斯综合征)中皮损的病程——一种初看可能被漏诊的疾病。
Am J Dermatopathol. 2015 Feb;37(2):e15-7. doi: 10.1097/DAD.0000000000000051.
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Refining the definition of hypereosinophilic syndrome.细化嗜酸性粒细胞增多综合征的定义。
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