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妊娠期心脏手术

Cardiac surgery in pregnancy.

作者信息

Barth William H

机构信息

Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

出版信息

Clin Obstet Gynecol. 2009 Dec;52(4):630-46. doi: 10.1097/GRF.0b013e3181bed9b5.

Abstract

The need for cardiac surgery during pregnancy is rare. Only 1% to 4% of pregnancies are complicated by maternal cardiac disease and most of these can be managed with medical therapy and lifestyle changes. On occasion, whether owing to natural progression of the underlying cardiac disease or precipitated by the cardiovascular changes of pregnancy, cardiac surgical therapy must be considered. Cardiac surgery is inherently dangerous for both, the mother and fetus with mortality rates near 10% and 30%, respectively. For some conditions, percutaneous cardiac intervention offers effective therapy with far less risk to the mother and her fetus. For others, cardiac surgery, including procedures that mandate the use of cardiopulmonary bypass, must be entertained to save the life of the mother. Given the extreme risks to the fetus, if the patient is in the third trimester, strong consideration should be given to delivery before surgery involving cardiopulmonary bypass. At earlier gestational ages when this is not feasible, modifications to the perfusion protocol including higher flow rates, normothermic perfusion, pulsatile flow, and the use of intraoperative external fetal heart rate monitoring should be considered.

摘要

孕期进行心脏手术的需求很少见。只有1%至4%的妊娠会并发母体心脏病,其中大多数可以通过药物治疗和生活方式改变来处理。有时,无论是由于潜在心脏病的自然进展还是由妊娠的心血管变化引发,都必须考虑心脏手术治疗。心脏手术对母亲和胎儿都具有内在危险性,死亡率分别接近10%和30%。对于某些情况,经皮心脏介入提供了有效治疗,对母亲及其胎儿的风险要小得多。对于其他情况,则必须考虑进行心脏手术,包括那些需要使用体外循环的手术,以挽救母亲的生命。鉴于对胎儿的极端风险,如果患者处于孕晚期,在涉及体外循环的手术前应强烈考虑分娩。在较早的孕周,当这不可行时,应考虑对灌注方案进行调整,包括更高的流速、常温灌注、搏动血流以及术中使用外部胎儿心率监测。

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