From the Division of Cardiology, Department of Medicine, New Jersey Medical School, Newark, NJ.
Cardiol Rev. 2010 May-Jun;18(3):125-31. doi: 10.1097/CRD.0b013e3181cfb646.
Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.
骨桥蛋白（OPN），也被称为 44kDa 骨磷蛋白、唾液蛋白 I、分泌磷蛋白 I、2ar、尿磷蛋白和早期 T 淋巴细胞激活-1（Eta-1），是一种多功能蛋白。OPN 已被发现存在于多种细胞类型和物种中，具有多种生理和病理功能。OPN 已成为心血管疾病中的一种潜在生物标志物和介质。在这篇综述中，我们将讨论 OPN 在心血管疾病中的作用，特别是在血管和瓣膜性心脏病、心肌梗死和心力衰竭中的作用。
