胃旁路手术后贫血发生的发生率和危险因素。
Incidence and risk factors for the development of anemia following gastric bypass surgery.
机构信息
Department of Surgery, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, United States.
出版信息
World J Gastroenterol. 2010 Apr 21;16(15):1867-70. doi: 10.3748/wjg.v16.i15.1867.
AIM
To evaluate the incidence and risk factors for the development of anemia after Roux-en-Y gastric bypass (RYGB).
METHODS
A retrospective analysis of patients undergoing RYGB from January 2003 to November 2007 was performed. All patients had a preoperative body mass index > 40 kg/m(2). A total of 206 patients were evaluated. All patients were given daily supplements of ferrous sulfate tablets for 2 wk following their operation. Hematological and metabolic indices were routinely evaluated following surgery. Patients were followed for a minimum of 86 wk.
RESULTS
There were 41 males and 165 females with an average age of 40.8 years. 21 patients (10.2%) developed post-operative anemia and 185 patients (89.8%) did not. Anemia was due to iron deficiency in all cases. The groups had similar demographics, surgical procedure and co-morbidities. Menstruation (P = 0.02) and peptic ulcer disease (P = 0.01) were risk factors for the development of post-operative anemia.
CONCLUSION
Iron deficiency anemia is frequent. RYGB surgery compounds occult blood loss. Increased ferrous sulfate supplementation may prevent iron depletion in populations at increased risk.
目的
评估 Roux-en-Y 胃旁路术（RYGB）后贫血的发生率和相关危险因素。
方法
对 2003 年 1 月至 2007 年 11 月行 RYGB 的患者进行回顾性分析。所有患者术前体重指数（BMI）>40kg/m²。共评估了 206 例患者。所有患者术后均连续 2 周每日服用硫酸亚铁片进行补铁。术后常规评估血液学和代谢指标。所有患者的随访时间均至少为 86 周。
结果
男性 41 例，女性 165 例，平均年龄 40.8 岁。21 例（10.2%）患者术后发生贫血，185 例（89.8%）患者未发生贫血。所有贫血均归因于缺铁。两组患者的人口统计学、手术过程和合并症均相似。月经（P=0.02）和消化性溃疡病（P=0.01）是术后贫血发生的危险因素。
结论
缺铁性贫血较为常见。RYGB 手术会导致隐匿性失血增加。增加硫酸亚铁的补充可能有助于预防高危人群的缺铁。
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