Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
World J Gastroenterol. 2010 Apr 21;16(15):1908-15. doi: 10.3748/wjg.v16.i15.1908.
To evaluate the induction of remission and maintenance effects of probiotics for ulcerative colitis.
Information was retrieved from MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The induction of remission and promotion of maintenance were compared between probiotics treatment and non-probiotics treatment in ulcerative colitis.
Thirteen randomized controlled studies met the selection criteria. Seven studies evaluated the remission rate, and eight studies estimated the recurrence rate; two studies evaluated both remission and recurrence rates. Compared with the non-probiotics group, the remission rate for ulcerative colitis patients who received probiotics was 1.35 (95% CI: 0.98-1.85). Compared with the placebo group, the remission rate of ulcerative colitis who received probiotics was 2.00 (95% CI: 1.35-2.96). During the course of treatment, in patients who received probiotics for less than 12 mo compared with the group treated by non-probiotics, the remission rate of ulcerative colitis was 1.36 (95% CI: 1.07-1.73). Compared with the non-probiotics group, the recurrence rate of ulcerative colitis patients who received probiotics was 0.69 (95% CI: 2.47-1.01). In the mild to moderate group who received probiotics, compared to the group who did not receive probiotics, the recurrence rate was 0.25 (95% CI: 0.12-0.51). The group who received Bifidobacterium bifidum treatment had a recurrence rate of 0.25 (95% CI: 0.12-0.50) compared with the non-probiotics group.
Probiotic treatment was more effective than placebo in maintaining remission in ulcerative colitis.
评估益生菌对溃疡性结肠炎的诱导缓解和维持效果。
检索 MEDLINE、EMBASE 和 Cochrane 对照试验注册库。比较益生菌治疗与溃疡性结肠炎非益生菌治疗的缓解率和维持率。
符合选择标准的有 13 项随机对照研究。7 项研究评估了缓解率，8 项研究估计了复发率；两项研究同时评估了缓解率和复发率。与非益生菌组相比，接受益生菌治疗的溃疡性结肠炎患者缓解率为 1.35（95%可信区间：0.98-1.85）。与安慰剂组相比，接受益生菌治疗的溃疡性结肠炎患者缓解率为 2.00（95%可信区间：1.35-2.96）。在治疗过程中，与接受非益生菌治疗的患者相比，接受益生菌治疗时间小于 12 个月的溃疡性结肠炎患者缓解率为 1.36（95%可信区间：1.07-1.73）。与非益生菌组相比，接受益生菌治疗的溃疡性结肠炎患者复发率为 0.69（95%可信区间：2.47-1.01）。在接受益生菌治疗的轻度至中度组中，与未接受益生菌治疗的组相比，复发率为 0.25（95%可信区间：0.12-0.51）。与非益生菌组相比，双歧杆菌治疗组的复发率为 0.25（95%可信区间：0.12-0.50）。
益生菌治疗在溃疡性结肠炎的维持缓解方面比安慰剂更有效。
