The La Fargue Group, Redondo Beach, CA 90278, USA.
Breast. 2010 Aug;19(4):303-6. doi: 10.1016/j.breast.2010.03.011. Epub 2010 Apr 15.
If breast cancer were viewed among siblings as a family of diseases, it might be easily identified as the favorite child. Policy, advocacy, and funding initiatives have supported this disease in such abundance that the "pink ribbon" has become almost synonymous in America with the terms "motherhood and apple pie". So, why have we still not found a cure after the launch of the war on cancer in the 1970s? This article delves deeply into the translational breast cancer research maze to capture thoughtful insights through interviews with noted researchers and by exploring the vision and strategies of major funders who invest in translational research. Common barriers within the United States systems are explored and compared to European models. Innovations that offer new paradigm shifts in the delivery of more timely, cost-effective, patient-centered, accountable, transparent, and collaborative research focused on responding to public health priorities and access are urgently needed to find the cure.
如果乳腺癌在兄弟姐妹中被视为一种疾病家族，那么它很容易被视为“宠儿”。政策、宣传和资助倡议如此丰富地支持这种疾病，以至于在美国，“粉红丝带”几乎已经成为“母亲和苹果派”的代名词。那么，自 20 世纪 70 年代发起癌症战争以来，我们为何仍未找到治愈方法？本文深入探讨了转化乳腺癌研究的迷宫，通过采访著名研究人员和探索投入转化研究的主要资助者的愿景和策略，捕捉到了深思熟虑的见解。文章还探讨了美国系统内的常见障碍，并与欧洲模式进行了比较。为了找到治愈方法，迫切需要提供新的范式转变，以便更及时、更具成本效益、以患者为中心、负责任、透明和协作的研究，以应对公共卫生优先事项和获取途径。
