Neuronal Networks Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Brain. 2010 May;133(Pt 5):1380-90. doi: 10.1093/brain/awq070. Epub 2010 Apr 16.
High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (>100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100-250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy.
高频皮层活动，特别是在 250-600 Hz（快纹波）频段，被认为在癫痫发生和发作产生中起着至关重要的作用。快纹波是癫痫起始区的高度特异性标志。然而，快纹波与癫痫灶之间的关联的证据取决于动物模型和人类病例，这些病例存在大量的病变，如海马硬化，这表明神经元丢失可能是快纹波产生的必要条件。在本工作中，我们使用缺乏海马硬化的颞叶癫痫非病变模型，测试细胞丢失是否是快纹波产生的必要前提。该模型是通过海马内单侧注射破伤风毒素诱导的。从自由移动的癫痫大鼠的海马中记录到高频活动（>100 Hz），包括快纹波。高频活动存在于发作间期放电和发作开始期间。发作间期快纹波比发作间期放电或纹波（100-250 Hz）更能可靠地作为原发性致痫区的标志。这些结果表明，在非病变性颞叶癫痫的术前评估中，应考虑快纹波活动的潜在价值。
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