Department of Psychosomatics in Children and Adolescents, Research Unit Child Public Health, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.
Qual Life Res. 2010 Aug;19(6):887-97. doi: 10.1007/s11136-010-9649-x. Epub 2010 Apr 17.
To examine the feasibility, reliability, and validity of the newly developed EQ-5D-Y.
The EQ-5D-Y was administered in population samples of children and adolescents in Germany, Italy, South Africa, Spain, and Sweden. Percentages of missing values and reported problems were calculated. Test-retest reliability was determined. Spearman's rank correlation coefficients with other generic measures of HRQOL were calculated. Known groups' validity was examined by comparing groups with a priori expected differences in HRQOL.
Between 91 and 100% of the respondents provided valid scorings. Sweden had the lowest proportion of reported problems (1-24.9% across EQ-5D-Y dimensions), with the highest proportions in South Africa (2.8-47.3%) and Italy (4.3-39.0%). Percentages of agreement in test-retest reliability ranged between 69.8 and 99.7% in the EQ-5D-Y dimensions; Kappa coefficients were up to 0.67. Correlation coefficients with other measures of self-rated health indicated convergent validity (up to r = -0.56). Differences between groups classified according to presence of chronic conditions, self-rated overall health and psychological problems provided preliminary evidence of known groups' validity.
Results provide preliminary evidence of the instrument's feasibility, reliability and validity. Further study is required in clinical samples and for possible future applications in economic analyses.
考察新开发的 EQ-5D-Y 的可行性、可靠性和有效性。
EQ-5D-Y 在德国、意大利、南非、西班牙和瑞典的儿童和青少年人群样本中进行了测试。计算了缺失值和报告问题的百分比。确定了重测信度。计算了与其他通用 HRQOL 衡量标准的斯皮尔曼等级相关系数。通过比较具有预期 HRQOL 差异的预先确定的组，检查了已知组的有效性。
91%至 100%的受访者提供了有效的评分。瑞典报告的问题比例最低（EQ-5D-Y 各维度为 1-24.9%），南非和意大利的比例最高（2.8-47.3%和 4.3-39.0%）。EQ-5D-Y 各维度的重测信度百分比在 69.8%至 99.7%之间；kappa 系数高达 0.67。与其他自我报告健康衡量标准的相关系数表明具有收敛效度（最高 r = -0.56）。根据存在慢性疾病、自我报告的总体健康状况和心理问题对组进行分类的差异，初步证明了已知组的有效性。
结果初步证明了该工具的可行性、可靠性和有效性。需要在临床样本中进行进一步研究，并可能在未来的经济分析中应用。
