血管紧张素转换酶抑制剂的使用与老年男性血清脱氢表雄酮浓度降低有关。

ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men.

机构信息

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

出版信息

Clin Chim Acta. 2010 Aug 5;411(15-16):1122-5. doi: 10.1016/j.cca.2010.04.011. Epub 2010 Apr 24.

DOI:10.1016/j.cca.2010.04.011

PMID:20403346

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883618/

Abstract

CONTEXT

Angiotensin converting enzyme (ACE) activity may influence the production of adrenal androgen precursors and testosterone. Use of ACE inhibitors may therefore have an influence on serum sex hormone concentrations in older men.

DESIGN AND METHODS

1486 out of 2,000 community-dwelling Chinese men aged 65years who participated in a cohort study were randomly selected to have archived fasting morning serum analyzed for androgen precursors and sex hormones. DNA was extracted from whole blood and analyzed for ACE gene I/D polymorphism.

RESULTS

Subjects with the ACE gene D allele (higher ACE activity) had higher serum dehydroepiandrosterone (DHEA) sulphate and DHEA than those with I/I genotype (P=0.014 and 0.018 respectively, Mann Whitney test). These differences were not significant after Bonferroni correction. Among those with history of hypertension, but without diabetes mellitus or cardiac failure, users of ACE inhibitors had significantly lower serum DHEA (median 1.78 versus 1.49ng/ml in non-users, P=0.0074, Mann Whitney test) and also tended to have lower serum androstenedione and androst-5-ene-3beta,17beta-diol (0.68 versus 0.72ng/ml in non-users; 552.4 versus 624.1pg/ml respectively, both P values <0.05). Serum testosterone and estradiol were not significantly changed.

CONCLUSIONS

ACE inhibitor use was associated with lower serum DHEA in older men.

摘要

背景

血管紧张素转换酶（ACE）的活性可能会影响肾上腺雄激素前体和睾酮的生成。因此，ACE 抑制剂的使用可能会对老年男性的血清性激素浓度产生影响。

设计和方法

从参与队列研究的 2000 名 65 岁的社区居住的中国男性中随机选择 1486 名，对其空腹清晨血清进行雄激素前体和性激素分析。从全血中提取 DNA，并分析 ACE 基因 I/D 多态性。

结果

携带 ACE 基因 D 等位基因（ACE 活性较高）的受试者血清脱氢表雄酮（DHEA）硫酸盐和 DHEA 水平高于 II 基因型（P=0.014 和 0.018，Mann Whitney 检验）。经过 Bonferroni 校正后，这些差异不再显著。在有高血压病史但无糖尿病或心力衰竭的患者中，ACE 抑制剂使用者的血清 DHEA 水平显著降低（中位数 1.78 与非使用者的 1.49ng/ml 相比，P=0.0074，Mann Whitney 检验），并且血清雄烯二酮和雄-5-烯-3β，17β-二醇也呈降低趋势（0.68 与非使用者的 0.72ng/ml 相比；552.4 与 624.1pg/ml 相比，两者的 P 值均<0.05）。血清睾酮和雌二醇没有明显变化。