Cacciari E, Corazza G R, Salardi S, Pascucci M G, Tacconi M, Cicognani A, Tassinari D, Biasco G, Volta U, Lazzari R
Department of Paediatrics, University of Bologna, Italy.
Eur J Pediatr. 1991 Apr;150(6):407-9. doi: 10.1007/BF02093719.
We studied three groups of patients with coeliac disease: group 1 = 95 adult patients with gastro-intestinal symptoms diagnosed after reaching adult height, 41 of whom had had symptoms during childhood; group 2 = 23 adult patients with classic coeliac disease treated before or during puberty; group 3 = 11 coeliac children with short stature and no gastro-intestinal symptoms diagnosed and treated before or during puberty. We evaluated the adult height in groups 1 and 2 and the growth during the first years of diet in group 3. Our study leads us to the following conclusions. Dieting leads to a modest increase (on average not more than 3 cm) of the final height of coeliac patients. Subjects with gastro-intestinal symptoms who have been treated before adulthood reach a mean height similar to the normal population and have a slightly better adult height than non-treated subjects. This difference seems to exist only in men and this might be related to puberty evolving more rapidly in women receiving treatment. Subjects without symptoms during childhood reach a normal final height even without treatment. In our patients, early treatment seemed to have no great effect on adult height.
第1组 = 95名成年患者,他们在达到成人身高后被诊断出患有胃肠道症状,其中41人在儿童时期就出现过症状;第2组 = 23名成年患者,患有典型乳糜泻,在青春期前或青春期期间接受过治疗;第3组 = 一组11名乳糜泻儿童,身材矮小,在青春期前或青春期期间被诊断出患有乳糜泻且无胃肠道症状。我们评估了第1组和第2组成年人的身高以及第3组在饮食治疗的头几年中的生长情况。我们的研究得出以下结论。饮食控制使乳糜泻患者的最终身高适度增加(平均不超过3厘米)。成年前接受治疗的有胃肠道症状的患者达到的平均身高与正常人群相似,且其成年身高略高于未接受治疗的患者。这种差异似乎仅存在于男性中,这可能与接受治疗的女性青春期发育更快有关。儿童时期无症状的患者即使未经治疗也能达到正常的最终身高。在我们的患者中,早期治疗似乎对成年身高没有太大影响。