Mäki M, Kallonen K, Lähdeaho M L, Visakorpi J K
Department of Paediatrics, University Central Hospital of Tampere, Finland.
Acta Paediatr Scand. 1988 May;77(3):408-12. doi: 10.1111/j.1651-2227.1988.tb10668.x.
In the Tampere region in Finland, the incidence of childhood coeliac disease was 1:1,096 between 1964 and 1973 and 1:3,214 from 1974 to 1983. The clinical picture of coeliac disease had changed to milder forms, resulting in an upward shift of age at diagnosis. Coeliac disease was found in older children and adolescents, manifesting itself mostly in minor abdominal symptoms, short stature, delayed puberty, anaemia and joint complaints, and in children with diabetes mellitus. Long breast-feeding seemed to postpone the symptoms but the introduction of gluten was of no significance. The low incidence for 1974 to 1983 was thought to be due to the estimated 20 cases born in 1979 to 1983 who were not detected. We do not believe that coeliac disease has disappeared but that it will be found during the next decade in the patients who were not diagnosed in school age and adolescence.
在芬兰坦佩雷地区，1964年至1973年期间儿童乳糜泻的发病率为1:1096，1974年至1983年期间为1:3214。乳糜泻的临床表现已转变为较轻的形式，导致诊断年龄上升。乳糜泻在大龄儿童和青少年中被发现，主要表现为轻微腹部症状、身材矮小、青春期延迟、贫血和关节不适，以及糖尿病患儿中出现。长时间母乳喂养似乎会推迟症状出现，但引入麸质并无显著影响。1974年至1983年的低发病率被认为是由于估计1979年至1983年出生的20例未被检测出的病例。我们不认为乳糜泻已经消失，而是认为在未来十年中会在学龄期和青春期未被诊断出的患者中发现。
